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@ARTICLE{Song:902074,
      author       = {Song, Mengmeng and Scheifele, Maximilian and Barthel,
                      Henryk and van Eimeren, Thilo and Beyer, Leonie and Marek,
                      Ken and Eckenweber, Florian and Palleis, Carla and Kaiser,
                      Lena and Finze, Anika and Kern, Maike and Nitschmann,
                      Alexander and Biechele, Gloria and Katzdobler, Sabrina and
                      Bischof, Gèrard and Hammes, Jochen and Jessen, Frank and
                      Saur, Dorothee and Schroeter, Matthias L. and Rumpf,
                      Jost-Julian and Rullmann, Michael and Schildan, Andreas and
                      Patt, Marianne and Neumaier, Bernd and Stephens, Andrew W.
                      and Rauchmann, Boris-Stephan and Perneczky, Robert and
                      Levin, Johannes and Classen, Joseph and Höglinger, Günter
                      U. and Bartenstein, Peter and Boening, Guido and Ziegler,
                      Sibylle and Villemagne, Victor and Drzezga, Alexander and
                      Seibyl, John and Sabri, Osama and Brendel, Matthias},
      title        = {{F}easibility of short imaging protocols for
                      [18{F}]{PI}-2620 tau-{PET} in progressive supranuclear
                      palsy},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {48},
      number       = {12},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2021-04014},
      pages        = {3872 - 3885},
      year         = {2021},
      abstract     = {PurposeDynamic 60-min positron emission tomography (PET)
                      imaging with the novel tau radiotracer [18F]PI-2620
                      facilitated accurate discrimination between patients with
                      progressive supranuclear palsy (PSP) and healthy controls
                      (HCs). This study investigated if truncated acquisition and
                      static time windows can be used for [18F]PI-2620 tau-PET
                      imaging of PSP.MethodsThirty-seven patients with PSP
                      Richardson syndrome (PSP-RS) were evaluated together with
                      ten HCs. [18F]PI-2620 PET was performed by a dynamic 60-min
                      scan. Distribution volume ratios (DVRs) were calculated
                      using full and truncated scan durations (0–60, 0–50,
                      0–40, 0–30, and 0–20 min p.i.). Standardized uptake
                      value ratios (SUVrs) were obtained 20–40, 30–50, and
                      40–60 min p.i.. All DVR and SUVr data were compared with
                      regard to their potential to discriminate patients with
                      PSP-RS from HCs in predefined subcortical and cortical
                      target regions (effect size, area under the curve (AUC),
                      multi-region classifier).Results0–50 and 0–40 DVR showed
                      equivalent effect sizes as 0–60 DVR (averaged Cohen’s d:
                      1.22 and 1.16 vs. 1.26), whereas the performance dropped for
                      0–30 or 0–20 DVR. The 20–40 SUVr indicated the best
                      performance of all static acquisition windows (averaged
                      Cohen’s d: 0.99). The globus pallidus internus
                      discriminated patients with PSP-RS and HCs at a similarly
                      high level for 0–60 DVR (AUC: 0.96), 0–40 DVR (AUC:
                      0.96), and 20–40 SUVr (AUC: 0.94). The multi-region
                      classifier sensitivity of these time windows was
                      consistently $86\%.ConclusionTruncated$ and static imaging
                      windows can be used for [18F]PI-2620 PET imaging of PSP.
                      0–40 min dynamic scanning offers the best balance between
                      accuracy and economic scanning.},
      cin          = {INM-3 / INM-2 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34021393},
      UT           = {WOS:000652954500002},
      doi          = {10.1007/s00259-021-05391-3},
      url          = {https://juser.fz-juelich.de/record/902074},
}