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000902080 1001_ $$0P:(DE-HGF)0$$aVay, Sabine Ulrike$$b0$$eCorresponding author
000902080 245__ $$aOsteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype
000902080 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2021
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000902080 520__ $$aThe glycoprotein osteopontin is highly upregulated in central nervous system (CNS) disorders such as ischemic stroke. Osteopontin regulates cell growth, cell adhesion, homeostasis, migration, and survival of various cell types. Accordingly, osteopontin is considered an essential regulator of regeneration and repair in the ischemic milieu. Astrocytes are the most abundant cells in the CNS and play significant roles in health and disease. Astrocytes are involved in homeostasis, promote neuroprotection, and regulate synaptic plasticity. Upon activation, astrocytes may adopt different phenotypes, termed A1 and A2. The direct effects of osteopontin on astrocytes, especially in distinct activation states, are yet unknown. The current study aimed to elucidate the impact of osteopontin on resting and active astrocytes. We established an inflammatory in vitro model of activated (A1) primary astrocytes derived from neonatal wistar rats by exposure to a distinct combination of proinflammatory cytokines. To model ischemic stroke in vitro, astrocytes were subjected to oxygen and glucose deprivation (OGD) in the presence or absence of osteopontin. Osteopontin modulated the activation phenotype by attenuating A1- and restoring A2-marker expression without compromising the active astrocytes’ immunocompetence. Osteopontin promoted the proliferation of active and the migration of resting astrocytes. Following transient OGD, osteopontin mitigated the delayed ongoing death of primary astrocytes, promoting their survival. Data suggest that osteopontin differentially regulates essential functions of resting and active astrocytes and confirm a significant regulatory role of osteopontin in an in vitro ischemia model. Furthermore, the data suggest that osteopontin constitutes a promising target for experimental therapies modulating neuroregeneration and repair.
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000902080 7001_ $$0P:(DE-HGF)0$$aOlschewski, Daniel Navin$$b1
000902080 7001_ $$0P:(DE-HGF)0$$aPetereit, Helena$$b2
000902080 7001_ $$0P:(DE-HGF)0$$aLange, Felix$$b3
000902080 7001_ $$0P:(DE-HGF)0$$aNazarzadeh, Nilufar$$b4
000902080 7001_ $$0P:(DE-HGF)0$$aGross, Elena$$b5
000902080 7001_ $$0P:(DE-HGF)0$$aRabenstein, Monika$$b6
000902080 7001_ $$0P:(DE-Juel1)186027$$aBlaschke, Stefan Johannes$$b7$$ufzj
000902080 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b8$$ufzj
000902080 7001_ $$0P:(DE-HGF)0$$aSchroeter, Michael$$b9
000902080 7001_ $$0P:(DE-HGF)0$$aRueger, Maria Adele$$b10
000902080 773__ $$0PERI:(DE-600)1474904-X$$a10.1002/jnr.24954$$gp. jnr.24954$$n11$$p2822-2843$$tJournal of neuroscience research$$v9$$x1097-4547$$y2021
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