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@ARTICLE{Amare:902161,
author = {Amare, Azmeraw T. and Schubert, Klaus Oliver and Hou,
Liping and Clark, Scott R. and Papiol, Sergi and Cearns,
Micah and Heilbronner, Urs and Degenhardt, Franziska and
Tekola-Ayele, Fasil and Hsu, Yi-Hsiang and Shekhtman,
Tatyana and Adli, Mazda and Akula, Nirmala and Akiyama,
Kazufumi and Ardau, Raffaella and Arias, Bárbara and Aubry,
Jean-Michel and Backlund, Lena and Bhattacharjee, Abesh
Kumar and Bellivier, Frank and Benabarre, Antonio and
Bengesser, Susanne and Biernacka, Joanna M. and Birner,
Armin and Brichant-Petitjean, Clara and Cervantes, Pablo and
Chen, Hsi-Chung and Chillotti, Caterina and Cichon, Sven and
Cruceanu, Cristiana and Czerski, Piotr M. and Dalkner, Nina
and Dayer, Alexandre and Del Zompo, Maria and DePaulo, J.
Raymond and Étain, Bruno and Jamain, Stephane and Falkai,
Peter and Forstner, Andreas J. and Frisen, Louise and Frye,
Mark A. and Fullerton, Janice M. and Gard, Sébastien and
Garnham, Julie S. and Goes, Fernando S. and
Grigoroiu-Serbanescu, Maria and Grof, Paul and Hashimoto,
Ryota and Hauser, Joanna and Herms, Stefan and Hoffmann, Per
and Hofmann, Andrea and Jiménez, Esther and Kahn,
Jean-Pierre and Kassem, Layla and Kuo, Po-Hsiu and Kato,
Tadafumi and Kelsoe, John R. and Kittel-Schneider, Sarah and
Kliwicki, Sebastian and König, Barbara and Kusumi, Ichiro
and Laje, Gonzalo and Landén, Mikael and Lavebratt,
Catharina and Leboyer, Marion and Leckband, Susan G. and
Tortorella, Alfonso and Manchia, Mirko and Martinsson, Lina
and McCarthy, Michael J. and McElroy, Susan L. and Colom,
Francesc and Mitjans, Marina and Mondimore, Francis M. and
Monteleone, Palmiero and Nievergelt, Caroline M. and
Nöthen, Markus M. and Novák, Tomas and O’Donovan, Claire
and Ozaki, Norio and Ösby, Urban and Pfennig, Andrea and
Potash, James B. and Reif, Andreas and Wray, Naomi R. and
Ripke, Stephan and Mattheisen, Manuel and Trzaskowski,
Maciej and Byrne, Enda M. and Abdellaoui, Abdel and Adams,
Mark J. and Agerbo, Esben and Air, Tracy M. and Andlauer,
Till F. M. and Bacanu, Silviu-Alin and Bækvad-Hansen, Marie
and Beekman, Aartjan T. F. and Bigdeli, Tim B. and Binder,
Elisabeth B. and Blackwood, Douglas H. R. and Bryois, Julien
and Buttenschøn, Henriette N. and Bybjerg-Grauholm, Jonas
and Cai, Na and Castelao, Enrique and Christensen, Jane
varregaard and Clarke, Toni-Kim and Coleman, Jonathan R. I.
and Colodro-Conde, Lucía and Couvy-Duchesne, Baptiste and
Craddock, Nick and Crawford, Gregory E. and Davies, Gail and
Deary, Ian J. and Degenhardt, Franziska and Derks, Eske M.
and Direk, Nese and Dolan, Conor V. and Dunn, Erin C. and
Eley, Thalia C. and Escott-Price, Valentina and Kiadeh,
Farnush Farhadi Hassan and Finucane, Hilary K. and Forstner,
Andreas J. and Frank, Josef and Gaspar, Héléna A. and
Gill, Michael and Goes, Fernando S. and Gordon, Scott D. and
Grove, Jakob and Hall, Lynsey S. and Hansen, Christine
Søholm and Hansen, Thomas F. and Herms, Stefan and Hickie,
Ian B. and Hoffmann, Per and Homuth, Georg and Horn, Carsten
and Hottenga, Jouke-Jan and Hougaard, David M. and Ising,
Marcus and Jansen, Rick and Jorgenson, Eric and Knowles,
James A. and Kohane, Isaac S. and Kraft, Julia and
Kretzschmar, Warren W. and Krogh, Jesper and Kutalik,
Zoltán and Li, Yihan and Lind, Penelope A. and MacIntyre,
Donald J. and MacKinnon, Dean F. and Maier, Robert M. and
Maier, Wolfgang and Marchini, Jonathan and Mbarek, Hamdi and
McGrath, Patrick and McGuffin, Peter and Medland, Sarah E.
and Mehta, Divya and Middeldorp, Christel M. and Mihailov,
Evelin and Milaneschi, Yuri and Milani, Lili and Mondimore,
Francis M. and Montgomery, Grant W. and Mostafavi, Sara and
Mullins, Niamh and Nauck, Matthias and Ng, Bernard and
Nivard, Michel G. and Nyholt, Dale R. and O’Reilly, Paul
F. and Oskarsson, Hogni and Owen, Michael J. and Painter,
Jodie N. and Pedersen, Carsten Bøcker and Pedersen,
Marianne Giørtz and Peterson, Roseann E. and Pettersson,
Erik and Peyrot, Wouter J. and Pistis, Giorgio and Posthuma,
Danielle and Quiroz, Jorge A. and Qvist, Per and Rice, John
P. and Riley, Brien P. and Rivera, Margarita and Mirza,
Saira Saeed and Schoevers, Robert and Schulte, Eva C. and
Shen, Ling and Shi, Jianxin and Shyn, Stanley I. and
Sigurdsson, Engilbert and Sinnamon, Grant C. B. and Smit,
Johannes H. and Smith, Daniel J. and Stefansson, Hreinn and
Steinberg, Stacy and Streit, Fabian and Strohmaier, Jana and
Tansey, Katherine E. and Teismann, Henning and Teumer,
Alexander and Thompson, Wesley and Thomson, Pippa A. and
Thorgeirsson, Thorgeir E. and Traylor, Matthew and
Treutlein, Jens and Trubetskoy, Vassily and Uitterlinden,
André G. and Umbricht, Daniel and Van der Auwera, Sandra
and van Hemert, Albert M. and Viktorin, Alexander and
Visscher, Peter M. and Wang, Yunpeng and Webb, Bradley T.
and Weinsheimer, Shantel Marie and Wellmann, Jürgen and
Willemsen, Gonneke and Witt, Stephanie H. and Wu, Yang and
Xi, Hualin S. and Yang, Jian and Zhang, Futao and Arolt,
Volker and Baune, Bernhard T. and Berger, Klaus and Boomsma,
Dorret I. and Cichon, Sven and Dannlowski, Udo and de Geus,
E. J. C. and DePaulo, J. Raymond and Domenici, Enrico and
Domschke, Katharina and Esko, Tõnu and Grabe, Hans J. and
Hamilton, Steven P. and Hayward, Caroline and Heath, Andrew
C. and Kendler, Kenneth S. and Kloiber, Stefan and Lewis,
Glyn and Li, Qingqin S. and Lucae, Susanne and Madden,
Pamela A. F. and Magnusson, Patrik K. and Martin, Nicholas
G. and McIntosh, Andrew M. and Metspalu, Andres and Mors,
Ole and Mortensen, Preben Bo and Müller-Myhsok, Bertram and
Nordentoft, Merete and Nöthen, Markus M. and O’Donovan,
Michael C. and Paciga, Sara A. and Pedersen, Nancy L. and
Penninx, Brenda W. J. H. and Perlis, Roy H. and Porteous,
David J. and Potash, James B. and Preisig, Martin and
Rietschel, Marcella and Schaefer, Catherine and Schulze,
Thomas G. and Smoller, Jordan W. and Stefansson, Kari and
Tiemeier, Henning and Uher, Rudolf and Völzke, Henry and
Weissman, Myrna M. and Werge, Thomas and Lewis, Cathryn M.
and Levinson, Douglas F. and Breen, Gerome and Børglum,
Anders D. and Sullivan, Patrick F. and Reininghaus, Eva and
Rouleau, Guy A. and Rybakowski, Janusz K. and Schalling,
Martin and Schofield, Peter R. and Schweizer, Barbara W. and
Severino, Giovanni and Shilling, Paul D. and Shimoda,
Katzutaka and Simhandl, Christian and Slaney, Claire M. and
Squassina, Alessio and Stamm, Thomas and Stopkova, Pavla and
Maj, Mario and Turecki, Gustavo and Vieta, Eduard and Veeh,
Julia and Witt, Stephanie H. and Wright, Adam and Zandi,
Peter P. and Mitchell, Philip B. and Bauer, Michael and
Alda, Martin and Rietschel, Marcella and McMahon, Francis J.
and Schulze, Thomas G. and Baune, Bernhard T.},
title = {{A}ssociation of polygenic score for major depression with
response to lithium in patients with bipolar disorder},
journal = {Molecular psychiatry},
volume = {26},
number = {6},
issn = {1476-5578},
address = {London},
publisher = {Macmillan},
reportid = {FZJ-2021-04070},
pages = {2457 - 2470},
year = {2021},
abstract = {Lithium is a first-line medication for bipolar disorder
(BD), but only one in three patients respond optimally to
the drug. Since evidence shows a strong clinical and genetic
overlap between depression and bipolar disorder, we
investigated whether a polygenic susceptibility to major
depression is associated with response to lithium treatment
in patients with BD. Weighted polygenic scores (PGSs) were
computed for major depression (MD) at different GWAS p value
thresholds using genetic data obtained from 2586 bipolar
patients who received lithium treatment and took part in the
Consortium on Lithium Genetics (ConLi+Gen) study. Summary
statistics from genome-wide association studies in MD
(135,458 cases and 344,901 controls) from the Psychiatric
Genomics Consortium (PGC) were used for PGS weighting.
Response to lithium treatment was defined by continuous
scores and categorical outcome (responders versus
non-responders) using measurements on the Alda scale.
Associations between PGSs of MD and lithium treatment
response were assessed using a linear and binary logistic
regression modeling for the continuous and categorical
outcomes, respectively. The analysis was performed for the
entire cohort, and for European and Asian sub-samples. The
PGSs for MD were significantly associated with lithium
treatment response in multi-ethnic, European or Asian
populations, at various p value thresholds. Bipolar patients
with a low polygenic load for MD were more likely to respond
well to lithium, compared to those patients with high
polygenic load [lowest vs highest PGS quartiles,
multi-ethnic sample: OR = 1.54 $(95\%$ CI: 1.18–2.01)
and European sample: OR = 1.75 $(95\%$ CI:
1.30–2.36)]. While our analysis in the Asian sample found
equivalent effect size in the same direction: OR = 1.71
$(95\%$ CI: 0.61–4.90), this was not statistically
significant. Using PGS decile comparison, we found a similar
trend of association between a high genetic loading for MD
and lower response to lithium. Our findings underscore the
genetic contribution to lithium response in BD and support
the emerging concept of a lithium-responsive biotype in BD.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32203155},
UT = {WOS:000519671200001},
doi = {10.1038/s41380-020-0689-5},
url = {https://juser.fz-juelich.de/record/902161},
}
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