%0 Journal Article
%A Schweitzer, Finja
%A Goereci, Yasemin
%A Franke, Christiana
%A Silling, Steffi
%A Bösl, Fabian
%A Maier, Franziska
%A Heger, Eva
%A Deiman, Birgit
%A Prüss, Harald
%A Onur, Oezguer A.
%A Klein, Florian
%A Fink, Gereon Rudolf
%A Di Cristanziano, Veronica
%A Warnke, Clemens
%T Cerebrospinal Fluid Analysis Post–COVID-19 Is Not Suggestive of Persistent Central Nervous System Infection
%J Annals of neurology
%V 91
%N 1
%@ 1531-8249
%C Hoboken, NJ
%I Wiley-Blackwell
%M FZJ-2021-04101
%P 150-157
%D 2022
%X This study was undertaken to assess whether SARS-CoV-2 causes a persistent central nervous system infection. SARS-CoV-2–specific antibody index and SARS-CoV-2 RNA were studied in cerebrospinal fluid following COVID-19. Cerebrospinal fluid was assessed between days 1 and 30 (n = 12), between days 31 and 90 (n = 8), or later than 90 days (post–COVID-19, n = 20) after COVID-19 diagnosis. SARS-CoV-2 RNA was absent in all patients, and in none of the 20 patients with post–COVID-19 syndrome were intrathecally produced anti–SARS-CoV-2 antibodies detected. The absence of evidence of SARS-CoV-2 in cerebrospinal fluid argues against a persistent central nervous system infection as a cause of neurological or neuropsychiatric post–COVID-19 syndrome. ANN NEUROL 2022;91:150–157
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34724243
%U <Go to ISI:>//WOS:000720889800001
%R 10.1002/ana.26262
%U https://juser.fz-juelich.de/record/902213