TY  - JOUR
AU  - Schweitzer, Finja
AU  - Goereci, Yasemin
AU  - Franke, Christiana
AU  - Silling, Steffi
AU  - Bösl, Fabian
AU  - Maier, Franziska
AU  - Heger, Eva
AU  - Deiman, Birgit
AU  - Prüss, Harald
AU  - Onur, Oezguer A.
AU  - Klein, Florian
AU  - Fink, Gereon Rudolf
AU  - Di Cristanziano, Veronica
AU  - Warnke, Clemens
TI  - Cerebrospinal Fluid Analysis Post–COVID-19 Is Not Suggestive of Persistent Central Nervous System Infection
JO  - Annals of neurology
VL  - 91
IS  - 1
SN  - 1531-8249
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - FZJ-2021-04101
SP  - 150-157
PY  - 2022
AB  - This study was undertaken to assess whether SARS-CoV-2 causes a persistent central nervous system infection. SARS-CoV-2–specific antibody index and SARS-CoV-2 RNA were studied in cerebrospinal fluid following COVID-19. Cerebrospinal fluid was assessed between days 1 and 30 (n = 12), between days 31 and 90 (n = 8), or later than 90 days (post–COVID-19, n = 20) after COVID-19 diagnosis. SARS-CoV-2 RNA was absent in all patients, and in none of the 20 patients with post–COVID-19 syndrome were intrathecally produced anti–SARS-CoV-2 antibodies detected. The absence of evidence of SARS-CoV-2 in cerebrospinal fluid argues against a persistent central nervous system infection as a cause of neurological or neuropsychiatric post–COVID-19 syndrome. ANN NEUROL 2022;91:150–157
LB  - PUB:(DE-HGF)16
C6  - pmid:34724243
UR  - <Go to ISI:>//WOS:000720889800001
DO  - DOI:10.1002/ana.26262
UR  - https://juser.fz-juelich.de/record/902213
ER  -