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000902248 1001_ $$00000-0003-3719-1464$$aRyzhykau, Yury L.$$b0
000902248 245__ $$aMolecular model of a sensor of two-component signaling system
000902248 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2021
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000902248 520__ $$aTwo-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator. The receptors (histidine kinases, chemoreceptors and photoreceptors) are often embedded in the membrane and have a similar modular structure. Chemoreceptors were shown to function in highly ordered arrays, with trimers of dimers being the smallest functional unit. However, much less is known about photoreceptors. Here, we use small-angle scattering (SAS) to show that detergent-solubilized sensory rhodopsin II in complex with its cognate transducer forms dimers at low salt concentration, which associate into trimers of dimers at higher buffer molarities. We then fit an atomistic model of the whole complex into the SAS data. The obtained results suggest that the trimer of dimers is "tripod"-shaped and that the contacts between the dimers occur only through their cytoplasmic regions, whereas the transmembrane regions remain unconnected.
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000902248 7001_ $$00000-0003-4078-4762$$aOrekhov, Philipp S.$$b1
000902248 7001_ $$00000-0002-7906-4634$$aRulev, Maksim I.$$b2
000902248 7001_ $$00000-0001-9218-0464$$aVlasov, Alexey V.$$b3
000902248 7001_ $$00000-0003-2265-4534$$aMelnikov, Igor A.$$b4
000902248 7001_ $$0P:(DE-Juel1)176195$$aVolkov, Dmytro A.$$b5
000902248 7001_ $$00000-0001-5955-900X$$aNikolaev, Mikhail Yu.$$b6
000902248 7001_ $$0P:(DE-Juel1)176570$$aZabelskii, Dmitrii V.$$b7
000902248 7001_ $$00000-0001-9551-5450$$aMurugova, Tatiana N.$$b8
000902248 7001_ $$00000-0001-9253-1156$$aChupin, Vladimir V.$$b9
000902248 7001_ $$00000-0003-2872-7976$$aRogachev, Andrey V.$$b10
000902248 7001_ $$00000-0001-8598-5491$$aGruzinov, Andrey Yu.$$b11
000902248 7001_ $$00000-0003-0830-5696$$aSvergun, Dmitri I.$$b12
000902248 7001_ $$00000-0003-0415-8334$$aBrennich, Martha E.$$b13
000902248 7001_ $$aGushchin, Ivan Yu.$$b14
000902248 7001_ $$00000-0002-5924-4734$$aSoler-Lopez, Montserrat$$b15
000902248 7001_ $$aBothe, Arne$$b16
000902248 7001_ $$aBüldt, Georg$$b17
000902248 7001_ $$00000-0001-5030-0122$$aLeonard, Gordon$$b18
000902248 7001_ $$00000-0003-1921-9830$$aEngelhard, Martin$$b19
000902248 7001_ $$00000-0002-4530-2980$$aKuklin, Alexander I.$$b20$$eCorresponding author
000902248 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin I.$$b21$$eCorresponding author
000902248 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-021-89613-6$$gVol. 11, no. 1, p. 10774$$n1$$p10774$$tScientific reports$$v11$$x2045-2322$$y2021
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