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@ARTICLE{Ryzhykau:902248,
author = {Ryzhykau, Yury L. and Orekhov, Philipp S. and Rulev, Maksim
I. and Vlasov, Alexey V. and Melnikov, Igor A. and Volkov,
Dmytro A. and Nikolaev, Mikhail Yu. and Zabelskii, Dmitrii
V. and Murugova, Tatiana N. and Chupin, Vladimir V. and
Rogachev, Andrey V. and Gruzinov, Andrey Yu. and Svergun,
Dmitri I. and Brennich, Martha E. and Gushchin, Ivan Yu. and
Soler-Lopez, Montserrat and Bothe, Arne and Büldt, Georg
and Leonard, Gordon and Engelhard, Martin and Kuklin,
Alexander I. and Gordeliy, Valentin I.},
title = {{M}olecular model of a sensor of two-component signaling
system},
journal = {Scientific reports},
volume = {11},
number = {1},
issn = {2045-2322},
address = {[London]},
publisher = {Macmillan Publishers Limited, part of Springer Nature},
reportid = {FZJ-2021-04118},
pages = {10774},
year = {2021},
abstract = {Two-component systems (TCS) are widespread signaling
systems present in all domains of life. TCS typically
consist of a signal receptor/transducer and a response
regulator. The receptors (histidine kinases, chemoreceptors
and photoreceptors) are often embedded in the membrane and
have a similar modular structure. Chemoreceptors were shown
to function in highly ordered arrays, with trimers of dimers
being the smallest functional unit. However, much less is
known about photoreceptors. Here, we use small-angle
scattering (SAS) to show that detergent-solubilized sensory
rhodopsin II in complex with its cognate transducer forms
dimers at low salt concentration, which associate into
trimers of dimers at higher buffer molarities. We then fit
an atomistic model of the whole complex into the SAS data.
The obtained results suggest that the trimer of dimers is
"tripod"-shaped and that the contacts between the dimers
occur only through their cytoplasmic regions, whereas the
transmembrane regions remain unconnected.},
cin = {IBI-7},
ddc = {600},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34031444},
UT = {WOS:000659113400019},
doi = {10.1038/s41598-021-89613-6},
url = {https://juser.fz-juelich.de/record/902248},
}