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@ARTICLE{Ryzhykau:902248,
      author       = {Ryzhykau, Yury L. and Orekhov, Philipp S. and Rulev, Maksim
                      I. and Vlasov, Alexey V. and Melnikov, Igor A. and Volkov,
                      Dmytro A. and Nikolaev, Mikhail Yu. and Zabelskii, Dmitrii
                      V. and Murugova, Tatiana N. and Chupin, Vladimir V. and
                      Rogachev, Andrey V. and Gruzinov, Andrey Yu. and Svergun,
                      Dmitri I. and Brennich, Martha E. and Gushchin, Ivan Yu. and
                      Soler-Lopez, Montserrat and Bothe, Arne and Büldt, Georg
                      and Leonard, Gordon and Engelhard, Martin and Kuklin,
                      Alexander I. and Gordeliy, Valentin I.},
      title        = {{M}olecular model of a sensor of two-component signaling
                      system},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-04118},
      pages        = {10774},
      year         = {2021},
      abstract     = {Two-component systems (TCS) are widespread signaling
                      systems present in all domains of life. TCS typically
                      consist of a signal receptor/transducer and a response
                      regulator. The receptors (histidine kinases, chemoreceptors
                      and photoreceptors) are often embedded in the membrane and
                      have a similar modular structure. Chemoreceptors were shown
                      to function in highly ordered arrays, with trimers of dimers
                      being the smallest functional unit. However, much less is
                      known about photoreceptors. Here, we use small-angle
                      scattering (SAS) to show that detergent-solubilized sensory
                      rhodopsin II in complex with its cognate transducer forms
                      dimers at low salt concentration, which associate into
                      trimers of dimers at higher buffer molarities. We then fit
                      an atomistic model of the whole complex into the SAS data.
                      The obtained results suggest that the trimer of dimers is
                      "tripod"-shaped and that the contacts between the dimers
                      occur only through their cytoplasmic regions, whereas the
                      transmembrane regions remain unconnected.},
      cin          = {IBI-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34031444},
      UT           = {WOS:000659113400019},
      doi          = {10.1038/s41598-021-89613-6},
      url          = {https://juser.fz-juelich.de/record/902248},
}