Home > Publications database > Molecular model of a sensor of two-component signaling system > print

001     902248
005     20220930130330.0
024 7 _ |a 10.1038/s41598-021-89613-6
|2 doi
024 7 _ |a 2128/29705
|2 Handle
024 7 _ |a altmetric:106834576
|2 altmetric
024 7 _ |a pmid:34031444
|2 pmid
024 7 _ |a WOS:000659113400019
|2 WOS
037 _ _ |a FZJ-2021-04118
082 _ _ |a 600
100 1 _ |a Ryzhykau, Yury L.
|0 0000-0003-3719-1464
|b 0
245 _ _ |a Molecular model of a sensor of two-component signaling system
260 _ _ |a [London]
|c 2021
|b Macmillan Publishers Limited, part of Springer Nature
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1640942291_23406
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator. The receptors (histidine kinases, chemoreceptors and photoreceptors) are often embedded in the membrane and have a similar modular structure. Chemoreceptors were shown to function in highly ordered arrays, with trimers of dimers being the smallest functional unit. However, much less is known about photoreceptors. Here, we use small-angle scattering (SAS) to show that detergent-solubilized sensory rhodopsin II in complex with its cognate transducer forms dimers at low salt concentration, which associate into trimers of dimers at higher buffer molarities. We then fit an atomistic model of the whole complex into the SAS data. The obtained results suggest that the trimer of dimers is "tripod"-shaped and that the contacts between the dimers occur only through their cytoplasmic regions, whereas the transmembrane regions remain unconnected.
536 _ _ |a 5241 - Molecular Information Processing in Cellular Systems (POF4-524)
|0 G:(DE-HGF)POF4-5241
|c POF4-524
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de
700 1 _ |a Orekhov, Philipp S.
|0 0000-0003-4078-4762
|b 1
700 1 _ |a Rulev, Maksim I.
|0 0000-0002-7906-4634
|b 2
700 1 _ |a Vlasov, Alexey V.
|0 0000-0001-9218-0464
|b 3
700 1 _ |a Melnikov, Igor A.
|0 0000-0003-2265-4534
|b 4
700 1 _ |a Volkov, Dmytro A.
|0 P:(DE-Juel1)176195
|b 5
700 1 _ |a Nikolaev, Mikhail Yu.
|0 0000-0001-5955-900X
|b 6
700 1 _ |a Zabelskii, Dmitrii V.
|0 P:(DE-Juel1)176570
|b 7
700 1 _ |a Murugova, Tatiana N.
|0 0000-0001-9551-5450
|b 8
700 1 _ |a Chupin, Vladimir V.
|0 0000-0001-9253-1156
|b 9
700 1 _ |a Rogachev, Andrey V.
|0 0000-0003-2872-7976
|b 10
700 1 _ |a Gruzinov, Andrey Yu.
|0 0000-0001-8598-5491
|b 11
700 1 _ |a Svergun, Dmitri I.
|0 0000-0003-0830-5696
|b 12
700 1 _ |a Brennich, Martha E.
|0 0000-0003-0415-8334
|b 13
700 1 _ |a Gushchin, Ivan Yu.
|b 14
700 1 _ |a Soler-Lopez, Montserrat
|0 0000-0002-5924-4734
|b 15
700 1 _ |a Bothe, Arne
|b 16
700 1 _ |a Büldt, Georg
|b 17
700 1 _ |a Leonard, Gordon
|0 0000-0001-5030-0122
|b 18
700 1 _ |a Engelhard, Martin
|0 0000-0003-1921-9830
|b 19
700 1 _ |a Kuklin, Alexander I.
|0 0000-0002-4530-2980
|b 20
|e Corresponding author
700 1 _ |a Gordeliy, Valentin I.
|0 P:(DE-Juel1)131964
|b 21
|e Corresponding author
773 _ _ |a 10.1038/s41598-021-89613-6
|g Vol. 11, no. 1, p. 10774
|0 PERI:(DE-600)2615211-3
|n 1
|p 10774
|t Scientific reports
|v 11
|y 2021
|x 2045-2322
856 4 _ |u https://juser.fz-juelich.de/record/902248/files/PDF.js%20viewer.pdf
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/902248/files/s41598-021-89613-6.pdf
909 C O |o oai:juser.fz-juelich.de:902248
|p openaire
|p open_access
|p OpenAPC
|p driver
|p VDB
|p openCost
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 7
|6 P:(DE-Juel1)176570
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 21
|6 P:(DE-Juel1)131964
913 1 _ |a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|1 G:(DE-HGF)POF4-520
|0 G:(DE-HGF)POF4-524
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Molecular and Cellular Information Processing
|9 G:(DE-HGF)POF4-5241
|x 0
914 1 _ |y 2021
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2021-02-03
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b SCI REP-UK : 2019
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2021-02-03
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-02-03
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2021-02-03
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2021-02-03
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2021-02-03
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2021-02-03
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2021-02-03
920 1 _ |0 I:(DE-Juel1)IBI-7-20200312
|k IBI-7
|l Strukturbiochemie
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)IBI-7-20200312
980 _ _ |a APC
980 1 _ |a APC
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21