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@ARTICLE{Orth:902348,
      author       = {Orth, Linda and Zweerings, Jana and Ibrahim, Camellia N.
                      and Neuner, Irene and Sarkheil, Pegah},
      title        = {{A}ltered functional connectivity during evaluation of
                      self-relevance in women with borderline personality
                      disorder},
      journal      = {NeuroImage: Clinical},
      volume       = {27},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-04197},
      pages        = {102324 -},
      year         = {2020},
      abstract     = {Self-relevant functional abnormalities and identity
                      disorders constitute the core psychopathological components
                      in borderline personality disorder (BPD). Evidence suggests
                      that appraising the relevance of environmental information
                      to the self may be altered in BPD. However, only a few
                      studies have examined self-relevance (SR) in BPD, and the
                      neural correlates of SR processing has not yet been
                      investigated in this patient group. The current study sought
                      to evaluate brain activation differences between female
                      patients with BPD and healthy controls during SR processing.
                      A task-based fMRI paradigm was applied to evaluate SR
                      processing in 23 female patients with BPD and 23 matched
                      healthy controls. Participants were presented with a set of
                      short sentences and were instructed to rate the stimuli. The
                      differences in fMRI signals between SR rating (task of
                      interest) and valence rating (control task) were examined.
                      During SR rating, participants showed elevated activations
                      of the cortical midline structures (CMS), known to be
                      involved in the processing of self-related stimuli.
                      Furthermore, we observed an elevated activation of the
                      supplementary motor area (SMA) and the regions belonging to
                      the mirror neuron system (MNS). Using whole-brain,
                      seed-based connectivity analysis on the task-based fMRI
                      data, we studied connectivity of networks anchored to the
                      main CMS regions. We found a discrepancy in the connectivity
                      pattern between patients and controls regarding connectivity
                      of the CMS regions with the basal ganglia-thalamus complex.
                      These observations have two main implications: First, they
                      confirm the involvement of the CMS in SR evaluations of our
                      stimuli and add evidence about the involvement of an
                      extended network including the MNS and the SMA in this task.
                      Second, the functional connectivity profile observed in BPD
                      provides evidence for an altered functional interplay
                      between the CMS and the brain regions involved in salience
                      detection and reward evaluation, including the basal ganglia
                      and the thalamus.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32702624},
      UT           = {WOS:000561850100011},
      doi          = {10.1016/j.nicl.2020.102324},
      url          = {https://juser.fz-juelich.de/record/902348},
}