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@ARTICLE{Janiri:902381,
      author       = {Janiri, Delfina and Moser, Dominik A. and Doucet, Gaelle E.
                      and Luber, Maxwell J. and Rasgon, Alexander and Lee, Won Hee
                      and Murrough, James W. and Sani, Gabriele and Eickhoff,
                      Simon B. and Frangou, Sophia},
      title        = {{S}hared {N}eural {P}henotypes for {M}ood and {A}nxiety
                      {D}isorders {A} {M}eta-{A}nalysis of 226 {T}ask-{R}elated
                      {F}unctional {I}maging {S}tudies},
      journal      = {Focus},
      volume       = {19},
      number       = {2},
      issn         = {1541-4108},
      address      = {Arlington, Va.},
      publisher    = {American Psychiatric Publ.},
      reportid     = {FZJ-2021-04215},
      pages        = {256 - 263},
      year         = {2021},
      note         = {Kein Post-print vorhanden},
      abstract     = {Importance: Major depressive disorder, bipolar disorder,
                      posttraumatic stress disorder, and anxiety disorders are
                      highly comorbid and have shared clinical features. It is not
                      yet known whether their clinical overlap is reflected at the
                      neurobiological level.Objective: To detect transdiagnostic
                      convergence in abnormalities in task-related brain
                      activation.Data source: Task-related functional magnetic
                      resonance imaging articles published in PubMed, Web of
                      Science, and Google Scholar during the last decade comparing
                      control individuals with patients with mood, posttraumatic
                      stress, and anxiety disorders were examined.Study selection:
                      Following Preferred Reporting Items for Systematic Reviews
                      and Meta-analyses reporting guidelines, articles were
                      selected if they reported stereotactic coordinates of
                      whole-brain-based activation differences between adult
                      patients and control individuals.Data extraction and
                      synthesis: Coordinates of case-control differences coded by
                      diagnosis and by cognitive domain based on the research
                      domain criteria were analyzed using activation likelihood
                      estimation.Main outcomes and measures: Identification of
                      transdiagnostic clusters of aberrant activation and
                      quantification of the contribution of diagnosis and
                      cognitive domain to each cluster.Results: A total of 367
                      experiments (major depressive disorder, 149; bipolar
                      disorder, 103; posttraumatic stress disorder, 55; and
                      anxiety disorders, 60) were included comprising observations
                      from 4507 patients and 4755 control individuals. Three
                      right-sided clusters of hypoactivation were identified
                      centered in the inferior prefrontal cortex/insula (volume,
                      2120 mm3), the inferior parietal lobule (volume, 1224 mm3),
                      and the putamen (volume, 888 mm3); diagnostic differences
                      were noted only in the putamen (χ23 = 8.66; P = .03), where
                      hypoactivation was more likely in bipolar disorder
                      (percentage contribution = $72.17\%).$ Tasks associated with
                      cognitive systems made the largest contribution to each
                      cluster (percentage contributions $>29\%).$ Clusters of
                      hyperactivation could only be detected using a less
                      stringent threshold. These were centered in the
                      perigenual/dorsal anterior cingulate cortex (volume, 2208
                      mm3), the left amygdala/parahippocampal gyrus (volume, 2008
                      mm3), and the left thalamus (volume, 1904 mm3). No
                      diagnostic differences were observed (χ23 < 3.06; P > .38),
                      while tasks associated with negative valence systems made
                      the largest contribution to each cluster (percentage
                      contributions $>49\%).$ All findings were robust to the
                      moderator effects of age, sex, and magnetic field strength
                      of the scanner and medication.Conclusions and relevance: In
                      mood disorders, posttraumatic stress disorder, and anxiety
                      disorders, the most consistent transdiagnostic abnormalities
                      in task-related brain activity converge in regions that are
                      primarily associated with inhibitory control and salience
                      processing. Targeting these shared neural phenotypes could
                      potentially mitigate the risk of affective morbidity in the
                      general population and improve outcomes in clinical
                      populations.Conflict of interest statementConflict of
                      Interest Disclosures: In the past 5 years, Dr Murrough has
                      provided consultation services to Boehreinger Ingelheim,
                      Sage Therapeutics, FSV7, Novartis, Allergan, Fortress
                      Biotech, Janssen Research and Development,
                      Medavante-Prophase, and Global Medical Education and has
                      received research support from Avanir Pharmaceuticals Inc.
                      Dr Murrough is named on a patent pending for neuropeptide Y
                      as a treatment for mood and anxiety disorders. No other
                      disclosures were reported.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1176/appi.focus.19206},
      url          = {https://juser.fz-juelich.de/record/902381},
}