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@ARTICLE{Eberle:902417,
      author       = {Eberle, Raphael J. and Olivier, Danilo S. and Amaral,
                      Marcos S. and Willbold, Dieter and Arni, Raghuvir K. and
                      Coronado, Monika A.},
      title        = {{P}romising {N}atural {C}ompounds against {F}lavivirus
                      {P}roteases: {C}itrus {F}lavonoids {H}esperetin and
                      {H}esperidin},
      journal      = {Plants},
      volume       = {10},
      number       = {10},
      issn         = {2223-7747},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-04239},
      pages        = {2183 -},
      year         = {2021},
      abstract     = {Ubiquitous in citrus plants, Hesperidin and Hesperetin
                      flavanones possess several biological functions, including
                      antiviral activity. Arbovirus infections pose an
                      ever-increasing threat to global healthcare systems. Among
                      the severe arboviral infections currently known are those
                      caused by members of the Flavivirus genus, for example,
                      Dengue Virus—DENV, Yellow Fever Virus—YFV, and West Nile
                      Virus—WNV. In this study, we characterize the inhibitory
                      effect of Hesperidin and Hesperetin against DENV2, YFV, and
                      WNV NS2B/NS3 proteases. We report the noncompetitive
                      inhibition of the NS2B/NS3pro by the two bioflavonoids with
                      half maximal inhibitory concentration (IC50) values <5 µM
                      for HST and <70 µM for HSD. The determined dissociation
                      constants (KD) of both flavonoids is significantly below the
                      threshold value of 30 µM. Our findings demonstrate that a
                      new generation of anti-flavivirus drugs could be developed
                      based on selective optimization of both molecules.},
      cin          = {IBI-7},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552) / 5241 -
                      Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF3-552 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34685992},
      UT           = {WOS:000716267400001},
      doi          = {10.3390/plants10102183},
      url          = {https://juser.fz-juelich.de/record/902417},
}