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000902429 0247_ $$2doi$$a10.1021/acs.chemrev.0c01122
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000902429 1001_ $$00000-0003-1284-967X$$aNguyen, Phuong H.$$b0
000902429 245__ $$aAmyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
000902429 260__ $$aWashington, DC$$bACS Publ.$$c2021
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000902429 520__ $$aProtein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (Aβ, tau), α-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research, respectively, for many years.
000902429 536__ $$0G:(DE-HGF)POF4-5244$$a5244 - Information Processing in Neuronal Networks (POF4-524)$$cPOF4-524$$fPOF IV$$x0
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000902429 7001_ $$00000-0003-1964-1900$$aRamamoorthy, Ayyalusamy$$b1
000902429 7001_ $$00000-0002-3683-1178$$aSahoo, Bikash R.$$b2
000902429 7001_ $$00000-0003-1547-3612$$aZheng, Jie$$b3
000902429 7001_ $$00000-0001-8013-0806$$aFaller, Peter$$b4
000902429 7001_ $$00000-0002-2355-3316$$aStraub, John E.$$b5
000902429 7001_ $$00000-0003-3666-2789$$aDominguez, Laura$$b6
000902429 7001_ $$00000-0002-9801-9273$$aShea, Joan-Emma$$b7
000902429 7001_ $$00000-0002-8225-4025$$aDokholyan, Nikolay V.$$b8
000902429 7001_ $$0P:(DE-HGF)0$$aDe Simone, Alfonso$$b9
000902429 7001_ $$00000-0002-7383-719X$$aMa, Buyong$$b10
000902429 7001_ $$0P:(DE-HGF)0$$aNussinov, Ruth$$b11
000902429 7001_ $$0P:(DE-HGF)0$$aNajafi, Saeed$$b12
000902429 7001_ $$00000-0003-1034-1768$$aNgo, Son Tung$$b13
000902429 7001_ $$00000-0001-7176-7813$$aLoquet, Antoine$$b14
000902429 7001_ $$0P:(DE-HGF)0$$aChiricotto, Mara$$b15
000902429 7001_ $$00000-0002-6299-3111$$aGanguly, Pritam$$b16
000902429 7001_ $$00000-0002-3838-6004$$aMcCarty, James$$b17
000902429 7001_ $$00000-0001-7021-7916$$aLi, Mai Suan$$b18
000902429 7001_ $$00000-0002-7425-587X$$aHall, Carol$$b19
000902429 7001_ $$00000-0003-3657-6100$$aWang, Yiming$$b20
000902429 7001_ $$00000-0002-1163-9745$$aMiller, Yifat$$b21
000902429 7001_ $$0P:(DE-HGF)0$$aMelchionna, Simone$$b22
000902429 7001_ $$0P:(DE-HGF)0$$aHabenstein, Birgit$$b23
000902429 7001_ $$0P:(DE-HGF)0$$aTimr, Stepan$$b24
000902429 7001_ $$0P:(DE-HGF)0$$aChen, Jiaxing$$b25
000902429 7001_ $$0P:(DE-HGF)0$$aHnath, Brianna$$b26
000902429 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b27
000902429 7001_ $$00000-0001-6216-8640$$aKayed, Rakez$$b28
000902429 7001_ $$0P:(DE-HGF)0$$aLesné, Sylvain$$b29
000902429 7001_ $$00000-0001-5814-3328$$aWei, Guanghong$$b30
000902429 7001_ $$00000-0003-0894-8069$$aSterpone, Fabio$$b31
000902429 7001_ $$00000-0003-0346-2270$$aDoig, Andrew J.$$b32
000902429 7001_ $$00000-0001-9110-5585$$aDerreumaux, Philippe$$b33$$eCorresponding author
000902429 773__ $$0PERI:(DE-600)2003609-7$$a10.1021/acs.chemrev.0c01122$$gVol. 121, no. 4, p. 2545 - 2647$$n4$$p2545 - 2647$$tChemical reviews$$v121$$x0009-2665$$y2021
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