TY  - JOUR
AU  - Postema, Merel C.
AU  - Hoogman, Martine
AU  - Ambrosino, Sara
AU  - Asherson, Philip
AU  - Banaschewski, Tobias
AU  - Bandeira, Cibele E.
AU  - Baranov, Alexandr
AU  - Bau, Claiton H. D.
AU  - Baumeister, Sarah
AU  - Baur-Streubel, Ramona
AU  - Bellgrove, Mark A.
AU  - Biederman, Joseph
AU  - Bralten, Janita
AU  - Brandeis, Daniel
AU  - Brem, Silvia
AU  - Buitelaar, Jan K.
AU  - Busatto, Geraldo F.
AU  - Castellanos, Francisco X.
AU  - Cercignani, Mara
AU  - Chaim-Avancini, Tiffany M.
AU  - Chantiluke, Kaylita C.
AU  - Christakou, Anastasia
AU  - Coghill, David
AU  - Conzelmann, Annette
AU  - Cubillo, Ana I.
AU  - Cupertino, Renata B.
AU  - Zeeuw, Patrick
AU  - Doyle, Alysa E.
AU  - Durston, Sarah
AU  - Earl, Eric A.
AU  - Epstein, Jeffery N.
AU  - Ethofer, Thomas
AU  - Fair, Damien A.
AU  - Fallgatter, Andreas J.
AU  - Faraone, Stephen V.
AU  - Frodl, Thomas
AU  - Gabel, Matt C.
AU  - Gogberashvili, Tinatin
AU  - Grevet, Eugenio H.
AU  - Haavik, Jan
AU  - Harrison, Neil A.
AU  - Hartman, Catharina A.
AU  - Heslenfeld, Dirk J.
AU  - Hoekstra, Pieter J.
AU  - Hohmann, Sarah
AU  - Høvik, Marie F.
AU  - Jernigan, Terry L.
AU  - Kardatzki, Bernd
AU  - Karkashadze, Georgii
AU  - Kelly, Clare
AU  - Kohls, Gregor
AU  - Konrad, Kerstin
AU  - Kuntsi, Jonna
AU  - Lazaro, Luisa
AU  - Lera-Miguel, Sara
AU  - Lesch, Klaus-Peter
AU  - Louza, Mario R.
AU  - Lundervold, Astri J.
AU  - Malpas, Charles B
AU  - Mattos, Paulo
AU  - McCarthy, Hazel
AU  - Namazova-Baranova, Leyla
AU  - Nicolau, Rosa
AU  - Nigg, Joel T.
AU  - Novotny, Stephanie E.
AU  - Oberwelland Weiss, Eileen
AU  - O'Gorman Tuura, Ruth L.
AU  - Oosterlaan, Jaap
AU  - Oranje, Bob
AU  - Paloyelis, Yannis
AU  - Pauli, Paul
AU  - Picon, Felipe A.
AU  - Plessen, Kerstin J.
AU  - Ramos-Quiroga, J. Antoni
AU  - Reif, Andreas
AU  - Reneman, Liesbeth
AU  - Rosa, Pedro G. P.
AU  - Rubia, Katya
AU  - Schrantee, Anouk
AU  - Schweren, Lizanne J. S.
AU  - Seitz, Jochen
AU  - Shaw, Philip
AU  - Silk, Tim J.
AU  - Skokauskas, Norbert
AU  - Soliva Vila, Juan C.
AU  - Stevens, Michael C.
AU  - Sudre, Gustavo
AU  - Tamm, Leanne
AU  - Tovar-Moll, Fernanda
AU  - Erp, Theo G. M.
AU  - Vance, Alasdair
AU  - Vilarroya, Oscar
AU  - Vives-Gilabert, Yolanda
AU  - Polier, Georg G.
AU  - Walitza, Susanne
AU  - Yoncheva, Yuliya N.
AU  - Zanetti, Marcus V.
AU  - Ziegler, Georg C.
AU  - Glahn, David C.
AU  - Jahanshad, Neda
AU  - Medland, Sarah E.
AU  - Thompson, Paul M.
AU  - Fisher, Simon E.
AU  - Franke, Barbara
AU  - Francks, Clyde
TI  - Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
JO  - The journal of child psychology and psychiatry
VL  - 62
IS  - 10
SN  - 0021-9630
CY  - Oxford
PB  - Wiley-Blackwell
M1  - FZJ-2021-04331
SP  - 1202 - 1219
PY  - 2021
AB  - ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s d from −0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
LB  - PUB:(DE-HGF)16
C6  - pmid:33748971
UR  - <Go to ISI:>//WOS:000631669300001
DO  - DOI:10.1111/jcpp.13396
UR  - https://juser.fz-juelich.de/record/902522
ER  -