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@ARTICLE{Klein:902536,
      author       = {Klein, Andreas and Albrecht, Anna Christina and Pietruszka,
                      Jörg},
      title        = {{C}hemoenzymatic {O}ne-{P}ot {P}rocess for the {S}ynthesis
                      of {T}etrahydroisoquinolines},
      journal      = {Catalysts},
      volume       = {11},
      number       = {11},
      issn         = {2073-4344},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-04338},
      pages        = {1389 -},
      year         = {2021},
      abstract     = {1,2,3,4‑Tetrahydyroisoquinolines form a valuable scaffold
                      for a variety of bioactive secondary metabolites and
                      commercial pharmaceuticals. Due to the harsh or complex
                      conditions of the conventional chemical synthesis of this
                      molecular motif, alternative mild reaction pathways are in
                      demand. Here we present an easy-to-operate chemoenzymatic
                      one-pot process for the synthesis of tetrahydroisoquinolines
                      starting from benzylic alcohols and an amino alcohol. We
                      initially demonstrate the oxidation of 12 benzylic alcohols
                      by a laccase/TEMPO system to the corresponding aldehydes,
                      which are subsequently integrated in a phosphate salt
                      mediated Pictet–Spengler reaction with m‑tyramine. The
                      reaction conditions of both individual reactions were
                      analyzed separately, adapted to each other, and a
                      straightforward one-pot process was developed. This enables
                      the production of 12 1,2,3,4‑tetrahydyroisoquinolines with
                      yields of up to $87\%$ with constant reaction conditions in
                      phosphate buffer and common laboratory glass bottles without
                      the supplementation of any additives.},
      cin          = {IBG-1 / IBOC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IBOC-20090406},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000725862600001},
      doi          = {10.3390/catal11111389},
      url          = {https://juser.fz-juelich.de/record/902536},
}