%0 Journal Article
%A Sauerbier, Anna
%A Loehrer, Philipp
%A Jost, Stefanie T.
%A Heil, Shania
%A Petry-Schmelzer, Jan N.
%A Herberg, Johanna
%A Bachon, Pia
%A Aloui, Salima
%A Gronostay, Alexandra
%A Klingelhoefer, Lisa
%A Baldermann, J. Carlos
%A Huys, Daniel
%A Nimsky, Christopher
%A Barbe, Michael T.
%A Fink, Gereon R.
%A Martinez-Martin, Pablo
%A Ray Chaudhuri, K.
%A Visser-Vandewalle, Veerle
%A Timmermann, Lars
%A Weintraub, Daniel
%A Dafsari, Haidar S.
%T Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease
%J Journal of neurology, neurosurgery, and psychiatry
%V 92
%N 12
%@ 0022-3050
%C London
%I BMJ Publishing Group
%M FZJ-2021-04339
%P 1313 - 1318
%D 2021
%X Background The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson’s disease (PD) are understudied.Objective To investigate clinical predictors of STN-DBS effects on ICB.Methods In this prospective, open-label, multicentre study in patients with PD undergoing bilateral STN-DBS, we assessed patients preoperatively and at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), PD Questionnaire-8, Non-Motor Symptom Scale (NMSS), Unified PD Rating Scale in addition to levodopa-equivalent daily dose total (LEDD-total) and dopamine agonists (LEDD-DA). Changes at follow-up were analysed with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We explored predictors of QUIP-RS changes using correlations and linear regressions. Finally, we dichotomised patients into ‘QUIP-RS improvement or worsening’ and analysed between-group differences.Results We included 55 patients aged 61.7 years±8.4 with 9.8 years±4.6 PD duration. QUIP-RS cut-offs and psychiatric assessments identified patients with preoperative ICB. In patients with ICB, QUIP-RS improved significantly. However, we observed considerable interindividual variability of clinically relevant QUIP-RS outcomes as 27.3% experienced worsening and 29.1% an improvement. In post hoc analyses, higher baseline QUIP-RS and lower baseline LEDD-DA were associated with greater QUIP-RS improvements. Additionally, the ‘QUIP-RS worsening’ group had more severe baseline impairment in the NMSS attention/memory domain.Conclusions Our results show favourable ICB outcomes in patients with higher preoperative ICB severity and lower preoperative DA doses, and worse outcomes in patients with more severe baseline attention/memory deficits. These findings emphasise the need for comprehensive non-motor and motor symptoms assessments in patients undergoing STN-DBS.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34510000
%U <Go to ISI:>//WOS:000722666700001
%R 10.1136/jnnp-2021-326131
%U https://juser.fz-juelich.de/record/902537