000902537 001__ 902537
000902537 005__ 20220103172046.0
000902537 0247_ $$2doi$$a10.1136/jnnp-2021-326131
000902537 0247_ $$2ISSN$$a0022-3050
000902537 0247_ $$2ISSN$$a0266-8637
000902537 0247_ $$2ISSN$$a0368-329X
000902537 0247_ $$2ISSN$$a1468-330X
000902537 0247_ $$2Handle$$a2128/29047
000902537 0247_ $$2altmetric$$aaltmetric:113296831
000902537 0247_ $$2pmid$$apmid:34510000
000902537 0247_ $$2WOS$$aWOS:000722666700001
000902537 037__ $$aFZJ-2021-04339
000902537 082__ $$a610
000902537 1001_ $$00000-0003-0966-5933$$aSauerbier, Anna$$b0$$eCorresponding author
000902537 245__ $$aPredictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease
000902537 260__ $$aLondon$$bBMJ Publishing Group$$c2021
000902537 3367_ $$2DRIVER$$aarticle
000902537 3367_ $$2DataCite$$aOutput Types/Journal article
000902537 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1637218635_27541
000902537 3367_ $$2BibTeX$$aARTICLE
000902537 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000902537 3367_ $$00$$2EndNote$$aJournal Article
000902537 520__ $$aBackground The effects of subthalamic stimulation (subthalamic nucleus-deep brain stimulation, STN-DBS) on impulsive and compulsive behaviours (ICB) in Parkinson’s disease (PD) are understudied.Objective To investigate clinical predictors of STN-DBS effects on ICB.Methods In this prospective, open-label, multicentre study in patients with PD undergoing bilateral STN-DBS, we assessed patients preoperatively and at 6-month follow-up postoperatively. Clinical scales included the Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS), PD Questionnaire-8, Non-Motor Symptom Scale (NMSS), Unified PD Rating Scale in addition to levodopa-equivalent daily dose total (LEDD-total) and dopamine agonists (LEDD-DA). Changes at follow-up were analysed with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We explored predictors of QUIP-RS changes using correlations and linear regressions. Finally, we dichotomised patients into ‘QUIP-RS improvement or worsening’ and analysed between-group differences.Results We included 55 patients aged 61.7 years±8.4 with 9.8 years±4.6 PD duration. QUIP-RS cut-offs and psychiatric assessments identified patients with preoperative ICB. In patients with ICB, QUIP-RS improved significantly. However, we observed considerable interindividual variability of clinically relevant QUIP-RS outcomes as 27.3% experienced worsening and 29.1% an improvement. In post hoc analyses, higher baseline QUIP-RS and lower baseline LEDD-DA were associated with greater QUIP-RS improvements. Additionally, the ‘QUIP-RS worsening’ group had more severe baseline impairment in the NMSS attention/memory domain.Conclusions Our results show favourable ICB outcomes in patients with higher preoperative ICB severity and lower preoperative DA doses, and worse outcomes in patients with more severe baseline attention/memory deficits. These findings emphasise the need for comprehensive non-motor and motor symptoms assessments in patients undergoing STN-DBS.
000902537 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000902537 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000902537 7001_ $$0P:(DE-HGF)0$$aLoehrer, Philipp$$b1
000902537 7001_ $$00000-0003-0477-2289$$aJost, Stefanie T.$$b2
000902537 7001_ $$0P:(DE-HGF)0$$aHeil, Shania$$b3
000902537 7001_ $$00000-0003-0749-3840$$aPetry-Schmelzer, Jan N.$$b4
000902537 7001_ $$0P:(DE-HGF)0$$aHerberg, Johanna$$b5
000902537 7001_ $$0P:(DE-HGF)0$$aBachon, Pia$$b6
000902537 7001_ $$0P:(DE-HGF)0$$aAloui, Salima$$b7
000902537 7001_ $$0P:(DE-HGF)0$$aGronostay, Alexandra$$b8
000902537 7001_ $$0P:(DE-HGF)0$$aKlingelhoefer, Lisa$$b9
000902537 7001_ $$00000-0001-5851-9268$$aBaldermann, J. Carlos$$b10
000902537 7001_ $$00000-0002-9124-4128$$aHuys, Daniel$$b11
000902537 7001_ $$0P:(DE-HGF)0$$aNimsky, Christopher$$b12
000902537 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b13
000902537 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b14
000902537 7001_ $$0P:(DE-HGF)0$$aMartinez-Martin, Pablo$$b15
000902537 7001_ $$0P:(DE-HGF)0$$aRay Chaudhuri, K.$$b16
000902537 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b17
000902537 7001_ $$0P:(DE-HGF)0$$aTimmermann, Lars$$b18
000902537 7001_ $$0P:(DE-HGF)0$$aWeintraub, Daniel$$b19
000902537 7001_ $$00000-0001-8849-4233$$aDafsari, Haidar S.$$b20
000902537 773__ $$0PERI:(DE-600)1480429-3$$a10.1136/jnnp-2021-326131$$gVol. 92, no. 12, p. 1313 - 1318$$n12$$p1313 - 1318$$tJournal of neurology, neurosurgery, and psychiatry$$v92$$x0022-3050$$y2021
000902537 8564_ $$uhttps://juser.fz-juelich.de/record/902537/files/Sauerbier_2021_J%20Neurol%20Neurosurg%20Psychiatry_Predictors%20of%20short-term...pdf$$yOpenAccess
000902537 909CO $$ooai:juser.fz-juelich.de:902537$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000902537 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b14$$kFZJ
000902537 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000902537 9141_ $$y2021
000902537 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ NEUROL NEUROSUR PS : 2019$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-27
000902537 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000902537 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000902537 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz$$d2021-01-27$$wger
000902537 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROL NEUROSUR PS : 2019$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2021-01-27
000902537 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-27$$wger
000902537 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-27
000902537 920__ $$lyes
000902537 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000902537 980__ $$ajournal
000902537 980__ $$aVDB
000902537 980__ $$aUNRESTRICTED
000902537 980__ $$aI:(DE-Juel1)INM-3-20090406
000902537 9801_ $$aFullTexts