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@ARTICLE{Sauerbier:902537,
      author       = {Sauerbier, Anna and Loehrer, Philipp and Jost, Stefanie T.
                      and Heil, Shania and Petry-Schmelzer, Jan N. and Herberg,
                      Johanna and Bachon, Pia and Aloui, Salima and Gronostay,
                      Alexandra and Klingelhoefer, Lisa and Baldermann, J. Carlos
                      and Huys, Daniel and Nimsky, Christopher and Barbe, Michael
                      T. and Fink, Gereon R. and Martinez-Martin, Pablo and Ray
                      Chaudhuri, K. and Visser-Vandewalle, Veerle and Timmermann,
                      Lars and Weintraub, Daniel and Dafsari, Haidar S.},
      title        = {{P}redictors of short-term impulsive and compulsive
                      behaviour after subthalamic stimulation in {P}arkinson
                      disease},
      journal      = {Journal of neurology, neurosurgery, and psychiatry},
      volume       = {92},
      number       = {12},
      issn         = {0022-3050},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {FZJ-2021-04339},
      pages        = {1313 - 1318},
      year         = {2021},
      abstract     = {Background The effects of subthalamic stimulation
                      (subthalamic nucleus-deep brain stimulation, STN-DBS) on
                      impulsive and compulsive behaviours (ICB) in Parkinson’s
                      disease (PD) are understudied.Objective To investigate
                      clinical predictors of STN-DBS effects on ICB.Methods In
                      this prospective, open-label, multicentre study in patients
                      with PD undergoing bilateral STN-DBS, we assessed patients
                      preoperatively and at 6-month follow-up postoperatively.
                      Clinical scales included the Questionnaire for
                      Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS),
                      PD Questionnaire-8, Non-Motor Symptom Scale (NMSS), Unified
                      PD Rating Scale in addition to levodopa-equivalent daily
                      dose total (LEDD-total) and dopamine agonists (LEDD-DA).
                      Changes at follow-up were analysed with Wilcoxon signed-rank
                      test and corrected for multiple comparisons (Bonferroni
                      method). We explored predictors of QUIP-RS changes using
                      correlations and linear regressions. Finally, we
                      dichotomised patients into ‘QUIP-RS improvement or
                      worsening’ and analysed between-group differences.Results
                      We included 55 patients aged 61.7 years±8.4 with 9.8
                      years±4.6 PD duration. QUIP-RS cut-offs and psychiatric
                      assessments identified patients with preoperative ICB. In
                      patients with ICB, QUIP-RS improved significantly. However,
                      we observed considerable interindividual variability of
                      clinically relevant QUIP-RS outcomes as $27.3\%$ experienced
                      worsening and $29.1\%$ an improvement. In post hoc analyses,
                      higher baseline QUIP-RS and lower baseline LEDD-DA were
                      associated with greater QUIP-RS improvements. Additionally,
                      the ‘QUIP-RS worsening’ group had more severe baseline
                      impairment in the NMSS attention/memory domain.Conclusions
                      Our results show favourable ICB outcomes in patients with
                      higher preoperative ICB severity and lower preoperative DA
                      doses, and worse outcomes in patients with more severe
                      baseline attention/memory deficits. These findings emphasise
                      the need for comprehensive non-motor and motor symptoms
                      assessments in patients undergoing STN-DBS.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34510000},
      UT           = {WOS:000722666700001},
      doi          = {10.1136/jnnp-2021-326131},
      url          = {https://juser.fz-juelich.de/record/902537},
}