% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@PHDTHESIS{Evcman:902559,
      author       = {Evcüman, Sibel},
      title        = {{S}ynthese 18{F}-markierter {PET}-{T}racer durch
                      nukleophile {K}upfer-vermittelte {R}adiofluorierung},
      volume       = {4430},
      school       = {Univ. Köln},
      type         = {Dissertation},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2021-04358, 4430},
      series       = {Berichte des Forschungszentrums Jülich},
      pages        = {VII, 187},
      year         = {2021},
      note         = {Dissertation, Univ. Köln, 2021},
      abstract     = {Positron emission tomography (PET) enables to detect
                      physiological and pathophysiological processeson the
                      cellular or molecular level. Therefore, PET has gained great
                      importance as a diagnostic imagingtechnique. Thus, a number
                      of neurological and neoplastic disordes are associated with
                      alterations inthe expression or activity of certain
                      receptors, transporters or enzymes, which can be visualized
                      andquantified using PET imaging. This is achieved by the
                      application of radiolabeled probes (tracers) thatselectively
                      interact with a molecular target of interest and can be
                      detected non-invasively based onthe emission of positrons.
                      Owing to its favorable half-live and the low energy of
                      emitted positrons,fluorine-18 is one of the most attractive
                      radionuclides for labeling of PET-tracers. A number of
                      noveltransition metal-mediated, late-stage radiofluorination
                      methods have enabled an easy access to 18Flabeledaromatic
                      systems regardless of their electronic properties. In
                      particular, Cu-mediatedradiofluorination with alcohols as
                      co-solvents has been shown to afford high radiochemical
                      yields(RCYs) of several clinically relevant PET tracers that
                      are hardly or not accessible by conventionalmethods.The aim
                      of the present work was to prepare 18F-labeled PET tracers
                      for different molecular targets byalcohol-enhanced
                      Cu-mediated radiofluorination and to evaluate their
                      properties by preclinicalexperiments in vitro and in vivo.
                      The molecular targets were selected based on their
                      pathophysiologicalrelevance and comprised the glycine
                      transporter 1 (GlyT1), the synaptic vesicle glycoprotein 2A
                      (SV2A)and the A1 adenosine receptor (A1AR). Following
                      identification of suitable high-affinity lead structures,the
                      corresponding precursor compounds were synthesized and
                      subsequently radiolabeled usingcopper-mediated
                      radiofluorination.},
      cin          = {INM-5},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      url          = {https://juser.fz-juelich.de/record/902559},
}