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001     902559
005     20220114140057.0
024 7 _ |2 Handle
|a 2128/30107
037 _ _ |a FZJ-2021-04358
088 _ _ |2 Other
|a 4430
100 1 _ |0 P:(DE-Juel1)165360
|a Evcüman, Sibel
|b 0
|e Corresponding author
|u fzj
245 _ _ |a Synthese 18F-markierter PET-Tracer durch nukleophile Kupfer-vermittelte Radiofluorierung
|f - 2021-07-21
260 _ _ |a Jülich
|b Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
|c 2021
300 _ _ |a VII, 187
336 7 _ |2 DataCite
|a Output Types/Dissertation
336 7 _ |0 PUB:(DE-HGF)3
|2 PUB:(DE-HGF)
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336 7 _ |2 ORCID
|a DISSERTATION
336 7 _ |2 BibTeX
|a PHDTHESIS
336 7 _ |0 2
|2 EndNote
|a Thesis
336 7 _ |0 PUB:(DE-HGF)11
|2 PUB:(DE-HGF)
|a Dissertation / PhD Thesis
|b phd
|m phd
|s 1641912287_22042
336 7 _ |2 DRIVER
|a doctoralThesis
490 0 _ |a Berichte des Forschungszentrums Jülich
|v 4430
502 _ _ |a Dissertation, Univ. Köln, 2021
|b Dissertation
|c Univ. Köln
|d 2021
520 _ _ |a Positron emission tomography (PET) enables to detect physiological and pathophysiological processeson the cellular or molecular level. Therefore, PET has gained great importance as a diagnostic imagingtechnique. Thus, a number of neurological and neoplastic disordes are associated with alterations inthe expression or activity of certain receptors, transporters or enzymes, which can be visualized andquantified using PET imaging. This is achieved by the application of radiolabeled probes (tracers) thatselectively interact with a molecular target of interest and can be detected non-invasively based onthe emission of positrons. Owing to its favorable half-live and the low energy of emitted positrons,fluorine-18 is one of the most attractive radionuclides for labeling of PET-tracers. A number of noveltransition metal-mediated, late-stage radiofluorination methods have enabled an easy access to 18Flabeledaromatic systems regardless of their electronic properties. In particular, Cu-mediatedradiofluorination with alcohols as co-solvents has been shown to afford high radiochemical yields(RCYs) of several clinically relevant PET tracers that are hardly or not accessible by conventionalmethods.The aim of the present work was to prepare 18F-labeled PET tracers for different molecular targets byalcohol-enhanced Cu-mediated radiofluorination and to evaluate their properties by preclinicalexperiments in vitro and in vivo. The molecular targets were selected based on their pathophysiologicalrelevance and comprised the glycine transporter 1 (GlyT1), the synaptic vesicle glycoprotein 2A (SV2A)and the A1 adenosine receptor (A1AR). Following identification of suitable high-affinity lead structures,the corresponding precursor compounds were synthesized and subsequently radiolabeled usingcopper-mediated radiofluorination.
536 _ _ |0 G:(DE-HGF)POF4-5253
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856 4 _ |u https://juser.fz-juelich.de/record/902559/files/J%C3%BCl_4430.pdf
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909 C O |o oai:juser.fz-juelich.de:902559
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|a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|v Decoding Brain Organization and Dysfunction
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914 1 _ |y 2021
915 _ _ |0 StatID:(DE-HGF)0510
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920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)INM-5-20090406
|k INM-5
|l Nuklearchemie
|x 0
980 _ _ |a phd
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a book
980 _ _ |a I:(DE-Juel1)INM-5-20090406
980 1 _ |a FullTexts

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