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@ARTICLE{LeClerc:902563,
      author       = {Le Clerc, Sigrid and Lombardi, Laura and Baune, Bernhard T.
                      and Amare, Azmeraw T. and Schubert, Klaus Oliver and Hou,
                      Liping and Clark, Scott R. and Papiol, Sergi and Cearns,
                      Micah and Heilbronner, Urs and Degenhardt, Franziska and
                      Tekola-Ayele, Fasil and Hsu, Yi-Hsiang and Shekhtman,
                      Tatyana and Adli, Mazda and Akula, Nirmala and Akiyama,
                      Kazufumi and Ardau, Raffaella and Arias, Bárbara and Aubry,
                      Jean-Michel and Backlund, Lena and Bhattacharjee, Abesh
                      Kumar and Bellivier, Frank and Benabarre, Antonio and
                      Bengesser, Susanne and Biernacka, Joanna M. and Birner,
                      Armin and Brichant-Petitjean, Clara and Cervantes, Pablo and
                      Chen, Hsi-Chung and Chillotti, Caterina and Cichon, Sven and
                      Cruceanu, Cristiana and Czerski, Piotr M. and Dalkner, Nina
                      and Dayer, Alexandre and Del Zompo, Maria and DePaulo, J.
                      Raymond and Étain, Bruno and Jamain, Stephane and Falkai,
                      Peter and Forstner, Andreas J. and Frisen, Louise and Frye,
                      Mark A. and Fullerton, Janice M. and Gard, Sébastien and
                      Garnham, Julie S. and Goes, Fernando S. and
                      Grigoroiu-Serbanescu, Maria and Grof, Paul and Hashimoto,
                      Ryota and Hauser, Joanna and Herms, Stefan and Hoffmann, Per
                      and Jiménez, Esther and Kahn, Jean-Pierre and Kassem, Layla
                      and Kuo, Po-Hsiu and Kato, Tadafumi and Kelsoe, John R. and
                      Kittel-Schneider, Sarah and Ferensztajn-Rochowiak, Ewa and
                      König, Barbara and Kusumi, Ichiro and Laje, Gonzalo and
                      Landén, Mikael and Lavebratt, Catharina and Leckband, Susan
                      G. and Tortorella, Alfonso and Manchia, Mirko and
                      Martinsson, Lina and McCarthy, Michael J. and McElroy, Susan
                      L. and Colom, Francesc and Millischer, Vincent and Mitjans,
                      Marina and Mondimore, Francis M. and Monteleone, Palmiero
                      and Nievergelt, Caroline M. and Nöthen, Markus M. and
                      Novák, Tomas and O’Donovan, Claire and Ozaki, Norio and
                      Ösby, Urban and Pfennig, Andrea and Potash, James B. and
                      Reif, Andreas and Reininghaus, Eva and Rouleau, Guy A. and
                      Rybakowski, Janusz K. and Schalling, Martin and Schofield,
                      Peter R. and Schweizer, Barbara W. and Severino, Giovanni
                      and Shilling, Paul D. and Shimoda, Katzutaka and Simhandl,
                      Christian and Slaney, Claire M. and Pisanu, Claudia and
                      Squassina, Alessio and Stamm, Thomas and Stopkova, Pavla and
                      Maj, Mario and Turecki, Gustavo and Vieta, Eduard and Veeh,
                      Julia and Witt, Stephanie H. and Wright, Adam and Zandi,
                      Peter P. and Mitchell, Philip B. and Bauer, Michael and
                      Alda, Martin and Rietschel, Marcella and McMahon, Francis J.
                      and Schulze, Thomas G. and Spadoni, Jean-Louis and
                      Boukouaci, Wahid and Richard, Jean-Romain and Le Corvoisier,
                      Philippe and Barrau, Caroline and Zagury, Jean-François and
                      Leboyer, Marion and Tamouza, Ryad},
      title        = {{HLA}-{DRB}1 and {HLA}-{DQB}1 genetic diversity modulates
                      response to lithium in bipolar affective disorders},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-04362},
      pages        = {17823},
      year         = {2021},
      abstract     = {Bipolar affective disorder (BD) is a severe psychiatric
                      illness, for which lithium (Li) is the gold standard for
                      acute and maintenance therapies. The therapeutic response to
                      Li in BD is heterogeneous and reliable biomarkers allowing
                      patients stratification are still needed. A GWAS performed
                      by the International Consortium on Lithium Genetics
                      (ConLiGen) has recently identified genetic markers
                      associated with treatment responses to Li in the human
                      leukocyte antigens (HLA) region. To better understand the
                      molecular mechanisms underlying this association, we have
                      genetically imputed the classical alleles of the HLA region
                      in the European patients of the ConLiGen cohort. We found
                      our best signal for amino-acid variants belonging to the
                      HLA-DRB1*11:01 classical allele, associated with a better
                      response to Li (p < 1 × 10−3; FDR < 0.09 in
                      the recessive model). Alanine or Leucine at position 74 of
                      the HLA-DRB1 heavy chain was associated with a good response
                      while Arginine or Glutamic acid with a poor response. As
                      these variants have been implicated in common
                      inflammatory/autoimmune processes, our findings strongly
                      suggest that HLA-mediated low inflammatory background may
                      contribute to the efficient response to Li in BD patients,
                      while an inflammatory status overriding Li anti-inflammatory
                      properties would favor a weak response.},
      cin          = {INM-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34497278},
      UT           = {WOS:000693895300003},
      doi          = {10.1038/s41598-021-97140-7},
      url          = {https://juser.fz-juelich.de/record/902563},
}