% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Deistung:902565,
      author       = {Deistung, A. and Jäschke, D. and Draganova, R. and
                      Pfaffenrot, V. and Hulst, T. and Steiner, K. M. and Thieme,
                      A. and Giordano, I. A. and Klockgether, T. and Tunc, S. and
                      Münchau, A. and Minnerop, Martina and Göricke, S. L. and
                      Reichenbach, J. R. and Timmann, D.},
      title        = {{Q}uantitative suspecptibility mapping reveals alterations
                      of denate nuclei in common types of ataxias},
      journal      = {Brain communications},
      volume       = {4},
      number       = {1},
      issn         = {2632-1297},
      address      = {[Großbritannien]},
      publisher    = {Guarantors of Brain},
      reportid     = {FZJ-2021-04364},
      pages        = {fcab306},
      year         = {2022},
      abstract     = {The cerebellar nuclei are a brain region with high iron
                      content. Surprisingly, little is known about iron content in
                      the cerebellar nuclei and its possible contribution to
                      pathology in cerebellar ataxias, with the only exception of
                      Friedreich’s ataxia. In the present exploratory
                      cross-sectional study, quantitative susceptibility mapping
                      was used to investigate volume, iron concentration and total
                      iron content of the dentate nuclei in common types of
                      hereditary and non-hereditary degenerative ataxias.
                      Seventy-nine patients with spinocerebellar ataxias of types
                      1, 2, 3 and 6; 15 patients with Friedreich’s ataxia; 18
                      patients with multiple system atrophy, cerebellar type and
                      111 healthy controls were also included. All underwent 3 T
                      MRI and clinical assessments. For each specific ataxia
                      subtype, voxel-based and volumes-of-interest-based group
                      analyses were performed in comparison with a corresponding
                      age- and sex-matched control group, both for volume,
                      magnetic susceptiblity (indicating iron concentration) and
                      susceptibility mass (indicating total iron content) of the
                      dentate nuclei. Spinocerebellar ataxia of type 1 and
                      multiple system atrophy, cerebellar type patients showed
                      higher susceptibilities in large parts of the dentate
                      nucleus but unaltered susceptibility masses compared with
                      controls. Friedreich’s ataxia patients and, only on a
                      trend level, spinocerebellar ataxia of type 2 patients
                      showed higher susceptibilities in more circumscribed parts
                      of the dentate. In contrast, spinocerebellar ataxia of type
                      6 patients revealed lower susceptibilities and
                      susceptibility masses compared with controls throughout the
                      dentate nucleus. Spinocerebellar ataxia of type 3 patients
                      showed no significant changes in susceptibility and
                      susceptibility mass. Lower volume of the dentate nuclei was
                      found to varying degrees in all ataxia types. It was most
                      pronounced in spinocerebellar ataxia of type 6 patients and
                      least prominent in spinocerebellar ataxia of type 3
                      patients. The findings show that alterations in
                      susceptibility revealed by quantitative susceptibility
                      mapping are common in the dentate nuclei in different types
                      of cerebellar ataxias. The most striking changes in
                      susceptibility were found in spinocerebellar ataxia of type
                      1, multiple system atrophy, cerebellar type and
                      spinocerebellar ataxia of type 6. Because iron content is
                      known to be high in glial cells but not in neurons of the
                      cerebellar nuclei, the higher susceptibility in
                      spinocerebellar ataxia of type 1 and multiple system
                      atrophy, cerebellar type may be explained by a reduction of
                      neurons (increase in iron concentration) and/or an increase
                      in iron-rich glial cells, e.g. microgliosis. Hypomyelination
                      also leads to higher susceptibility and could also
                      contribute. The lower susceptibility in SCA6 suggests a loss
                      of iron-rich glial cells. Quantitative susceptibility maps
                      warrant future studies of iron content and iron-rich cells
                      in ataxias to gain a more comprehensive understanding of the
                      pathogenesis of these diseases.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35291442},
      UT           = {WOS:000804710200027},
      doi          = {10.1093/braincomms/fcab306},
      url          = {https://juser.fz-juelich.de/record/902565},
}