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000902920 1001_ $$0P:(DE-Juel1)176593$$aMorales-Gregorio, Aitor$$b0$$eCorresponding author$$ufzj
000902920 1112_ $$a5th BigBrain Workshop$$cVirtual$$d2021-09-21 - 2021-09-23$$wGermany
000902920 245__ $$a3D reconstruction and analysis of the macaque brain from histological slices
000902920 260__ $$c2021
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000902920 520__ $$aGiven the usefulness of the BigBrain high resolution histological volume, it would be very valuable to have a similar public domain resource for the macaque. Isotropic high resolution data to build such a resource is not currently available, but as an initial step we present a histological volume based on the NIH Blueprint Non-Human Primate (NHP) Atlas [1], acquired by the Allen Institute and funded by the NIH. Our contribution is to take the set of Nissl stained slices (50 μm thick, 250 μm apart) and to create a smooth volume by calculating the optimal alignment. We used open tools [2, 3] for processing, modernized the code of the poSSum three-dimensional reconstruction toolbox [4] and extended the deformable registration method thereof, using the an MRI-based macaque atlas [5] as a reference template. We will use the reconstructed volume to estimate neuron densities across all cortical areas used in the core-nets.org macaque connectivity database [6]. Besides adding to the body of knowledge on the cytoarchitecture [7] and geometry of the macaque cortex, this work will provide tools to further analyze histological data and support large-scale dynamical modeling studies.[1] NIH Blueprint NHP Atlas, www.blueprintnhpatlas.org[2] Bakker et al. Neuroinformatics, 2015[3] Microdraw, microdraw.pasteur.fr[4] Majka et al. Journal of Comparative Neurology, 2016[5] Calabrese et al. NeuroImage, 2015[6] Markov et al. Cerebral Cortex, 2012[7] Beul and Hilgetag. NeuroImage, 2019
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000902920 536__ $$0G:(EU-Grant)945539$$aHBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)$$c945539$$fH2020-SGA-FETFLAG-HBP-2019$$x1
000902920 536__ $$0G:(GEPRIS)347572269$$aDFG project 347572269 - Heterogenität von Zytoarchitektur, Chemoarchitektur und Konnektivität in einem großskaligen Computermodell der menschlichen Großhirnrinde (347572269)$$c347572269$$x2
000902920 7001_ $$0P:(DE-Juel1)145578$$aBakker, Rembrandt$$b1$$eCorresponding author$$ufzj
000902920 7001_ $$0P:(DE-Juel1)138512$$avan Albada, Sacha$$b2$$ufzj
000902920 8564_ $$uhttps://juser.fz-juelich.de/record/902920/files/MoralesBakker_BigBrain_20210922-1.pdf$$yOpenAccess
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000902920 9141_ $$y2021
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000902920 9201_ $$0I:(DE-Juel1)IAS-6-20130828$$kIAS-6$$lTheoretical Neuroscience$$x1
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