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000009032 0247_ $$2DOI$$a10.3389/fnsyn.2010.00002
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000009032 041__ $$aeng
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000009032 1001_ $$0P:(DE-Juel1)VDB33818$$aRollenhagen, A.$$b0$$uFZJ
000009032 245__ $$aThe mossy fiber bouton: the "common" or the "unique" synapse?
000009032 260__ $$aLausanne$$bFrontiers Research Foundation$$c2010
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000009032 440_0 $$022123$$aFrontiers in Synaptic Neuroscience$$v2$$x1663-3563$$y2
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000009032 520__ $$aSynapses are the key elements for signal processing and plasticity in the brain. They are composed of nearly the same structural subelements, an apposition zone including a pre- and postsynaptic density, a cleft and a pool of vesicles. It is, however, their actual composition that determines their different behavior in synaptic transmission and plasticity. Here, we describe and discuss the structural factors underlying the unique functional properties of the hippocampal mossy fiber (MF) synapse. Two membrane specializations, active zones (AZs; transmitter release sites), and puncta adherentia (PA), putative adhesion complexes were found. On average, individual boutons had ∼20 AZs with a mean surface area of 0.1 μm(2) and a short distance of 0.45 μm between individual AZs. Mossy fiber boutons (MFBs) and their target structures were isolated from each other by astrocytes, but fine glial processes never reached the AZs. Therefore, two structural factors are likely to promote synaptic cross-talk: the short distance and the absence of fine glial processes between individual AZs. Thus, synaptic crosstalk may contribute to the high efficacy of hippocampal MF synapses. On average, an adult bouton contained ∼16,000 synaptic vesicles; ∼600 vesicles were located within 60 nm from the AZ, ∼4000 between 60 nm and 200 nm, and the remaining beyond 200 nm, suggesting large readily releasable, recycling, and reserve pools. Thus, the size of the three pools together with the number and distribution of AZs underlie the unique extent of synaptic efficacy and plasticity of the hippocampal MF synapse.
000009032 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000009032 588__ $$aDataset connected to Pubmed
000009032 7001_ $$0P:(DE-Juel1)VDB86960$$aLübke, J.H.R.$$b1$$uFZJ
000009032 773__ $$0PERI:(DE-600)2592086-8$$a10.3389/fnsyn.2010.00002$$gp. 1 - 9$$p1 - 9$$q1 - 9$$tFrontiers in synaptic neuroscience$$x1663-3563$$y2010
000009032 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059708
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000009032 9141_ $$y2010
000009032 915__ $$0StatID:(DE-HGF)0020$$aNo peer review
000009032 9201_ $$0I:(DE-Juel1)INM-2-20090406$$gINM$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
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