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@ARTICLE{Rollenhagen:9032,
      author       = {Rollenhagen, A. and Lübke, J.H.R.},
      title        = {{T}he mossy fiber bouton: the "common" or the "unique"
                      synapse?},
      journal      = {Frontiers in synaptic neuroscience},
      volume       = {2},
      issn         = {1663-3563},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {PreJuSER-9032},
      pages        = {1 - 9},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Synapses are the key elements for signal processing and
                      plasticity in the brain. They are composed of nearly the
                      same structural subelements, an apposition zone including a
                      pre- and postsynaptic density, a cleft and a pool of
                      vesicles. It is, however, their actual composition that
                      determines their different behavior in synaptic transmission
                      and plasticity. Here, we describe and discuss the structural
                      factors underlying the unique functional properties of the
                      hippocampal mossy fiber (MF) synapse. Two membrane
                      specializations, active zones (AZs; transmitter release
                      sites), and puncta adherentia (PA), putative adhesion
                      complexes were found. On average, individual boutons had
                      ∼20 AZs with a mean surface area of 0.1 μm(2) and a
                      short distance of 0.45 μm between individual AZs. Mossy
                      fiber boutons (MFBs) and their target structures were
                      isolated from each other by astrocytes, but fine glial
                      processes never reached the AZs. Therefore, two structural
                      factors are likely to promote synaptic cross-talk: the short
                      distance and the absence of fine glial processes between
                      individual AZs. Thus, synaptic crosstalk may contribute to
                      the high efficacy of hippocampal MF synapses. On average, an
                      adult bouton contained ∼16,000 synaptic vesicles; ∼600
                      vesicles were located within 60 nm from the AZ, ∼4000
                      between 60 nm and 200 nm, and the remaining beyond
                      200 nm, suggesting large readily releasable, recycling,
                      and reserve pools. Thus, the size of the three pools
                      together with the number and distribution of AZs underlie
                      the unique extent of synaptic efficacy and plasticity of the
                      hippocampal MF synapse.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21423488},
      pmc          = {pmc:PMC3059708},
      doi          = {10.3389/fnsyn.2010.00002},
      url          = {https://juser.fz-juelich.de/record/9032},
}