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@ARTICLE{Srikantharajah:903290,
      author       = {Srikantharajah, Kagithiri and Medinaceli Quintela, Renata
                      and Doerenkamp, Kerstin and Kampa, Björn M. and Musall,
                      Simon and Rothermel, Markus and Offenhäusser, Andreas},
      title        = {{M}inimally-invasive insertion strategy and in vivo
                      evaluation of multi-shank flexible intracortical probes},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-04986},
      pages        = {18920},
      year         = {2021},
      abstract     = {Chronically implanted neural probes are powerful tools to
                      decode brain activity however, recording population and
                      spiking activity over long periods remains a major
                      challenge. Here, we designed and fabricated flexible
                      intracortical Michigan-style arrays with a shank
                      cross-section per electrode of 250 μm2 utilizing the
                      polymer paryleneC with the goal to improve the immune
                      acceptance. As flexible neural probes are unable to
                      penetrate the brain due to the low buckling force threshold,
                      a tissue-friendly insertion system was developed by reducing
                      the effective shank length. The insertion strategy enabled
                      the implantation of the four, bare, flexible shanks up to 2
                      mm into the mouse brain without increasing the implantation
                      footprint and therefore, minimizing the acute trauma. In
                      acute recordings from the mouse somatosensory cortex and the
                      olfactory bulb, we demonstrated that the flexible probes
                      were able to simultaneously detect local field potentials as
                      well as single and multi-unit activity. Additionally, the
                      flexible arrays outperformed stiff probes with respect to
                      yield of single unit activity. Following the successful in
                      vivo validation, we further improved the microfabrication
                      towards a double-metal-layer process, and were able to
                      double the number of electrodes per shank by keeping the
                      shank width resulting in a cross-section per electrode of
                      118 μm2.},
      cin          = {IBI-3},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523)},
      pid          = {G:(DE-HGF)POF4-5231},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34556704},
      UT           = {WOS:000698791600068},
      doi          = {10.1038/s41598-021-97940-x},
      url          = {https://juser.fz-juelich.de/record/903290},
}