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000903435 005__ 20211212011922.0
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000903435 1001_ $$00000-0003-3142-7480$$aHansen, Justine Y.$$b0
000903435 245__ $$aMapping neurotransmitter systems to the structural and functional organization of the human neocortex
000903435 260__ $$c2021
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000903435 520__ $$aNeurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography scans in >1200 healthy individuals to construct a whole-brain 3-D normative atlas of 18 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
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000903435 7001_ $$00000-0002-2036-5571$$aShafiei, Golia$$b1
000903435 7001_ $$00000-0003-1057-1336$$aMarkello, Ross D.$$b2
000903435 7001_ $$00000-0002-4775-6943$$aSmart, Kelly$$b3
000903435 7001_ $$aCox, Sylvia M. L.$$b4
000903435 7001_ $$aWu, Yanjun$$b5
000903435 7001_ $$00000-0003-0399-8374$$aGallezot, Jean-Dominique$$b6
000903435 7001_ $$00000-0002-8997-7090$$aAumont, Étienne$$b7
000903435 7001_ $$aServaes, Stijn$$b8
000903435 7001_ $$aScala, Stephanie G.$$b9
000903435 7001_ $$00000-0002-4629-8354$$aDuBois, Jonathan M.$$b10
000903435 7001_ $$00000-0002-8106-6647$$aWainstein, Gabriel$$b11
000903435 7001_ $$00000-0002-1069-9201$$aBezgin, Gleb$$b12
000903435 7001_ $$aFunck, Thomas$$b13
000903435 7001_ $$00000-0003-0585-7524$$aSchmitz, Taylor W.$$b14
000903435 7001_ $$00000-0003-1530-8916$$aSpreng, R. Nathan$$b15
000903435 7001_ $$00000-0002-8422-2326$$aSoucy, Jean-Paul$$b16
000903435 7001_ $$00000-0002-6762-5713$$aBaillet, Sylvain$$b17
000903435 7001_ $$00000-0002-1582-725X$$aGuimond, Synthia$$b18
000903435 7001_ $$00000-0002-3179-6780$$aHietala, Jarmo$$b19
000903435 7001_ $$aBédard, Marc-André$$b20
000903435 7001_ $$00000-0002-1243-2252$$aLeyton, Marco$$b21
000903435 7001_ $$00000-0002-1713-1563$$aKobayashi, Eliane$$b22
000903435 7001_ $$00000-0001-9116-1376$$aRosa-Neto, Pedro$$b23
000903435 7001_ $$0P:(DE-Juel1)131701$$aPalomero-Gallagher, Nicola$$b24
000903435 7001_ $$00000-0003-1762-5499$$aShine, James M.$$b25
000903435 7001_ $$aCarson, Richard E.$$b26
000903435 7001_ $$00000-0002-8726-0467$$aTuominen, Lauri$$b27
000903435 7001_ $$00000-0002-0945-5779$$aDagher, Alain$$b28
000903435 7001_ $$00000-0003-0307-2862$$aMisic, Bratislav$$b29$$eCorresponding author
000903435 773__ $$a10.1101/2021.10.28.466336
000903435 8564_ $$uhttps://juser.fz-juelich.de/record/903435/files/HAnsen_etal_bioRxiv_2021_preprint.pdf$$yOpenAccess
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