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@ARTICLE{Hansen:903435,
      author       = {Hansen, Justine Y. and Shafiei, Golia and Markello, Ross D.
                      and Smart, Kelly and Cox, Sylvia M. L. and Wu, Yanjun and
                      Gallezot, Jean-Dominique and Aumont, Étienne and Servaes,
                      Stijn and Scala, Stephanie G. and DuBois, Jonathan M. and
                      Wainstein, Gabriel and Bezgin, Gleb and Funck, Thomas and
                      Schmitz, Taylor W. and Spreng, R. Nathan and Soucy,
                      Jean-Paul and Baillet, Sylvain and Guimond, Synthia and
                      Hietala, Jarmo and Bédard, Marc-André and Leyton, Marco
                      and Kobayashi, Eliane and Rosa-Neto, Pedro and
                      Palomero-Gallagher, Nicola and Shine, James M. and Carson,
                      Richard E. and Tuominen, Lauri and Dagher, Alain and Misic,
                      Bratislav},
      title        = {{M}apping neurotransmitter systems to the structural and
                      functional organization of the human neocortex},
      reportid     = {FZJ-2021-05115},
      year         = {2021},
      abstract     = {Neurotransmitter receptors support the propagation of
                      signals in the human brain. How receptor systems are
                      situated within macroscale neuroanatomy and how they shape
                      emergent function remains poorly understood, and there
                      exists no comprehensive atlas of receptors. Here we collate
                      positron emission tomography scans in >1200 healthy
                      individuals to construct a whole-brain 3-D normative atlas
                      of 18 receptors and transporters across 9 different
                      neurotransmitter systems. We find that receptor profiles
                      align with structural connectivity and mediate function,
                      including neurophysiological oscillatory dynamics and
                      resting state hemodynamic functional connectivity. Using the
                      Neurosynth cognitive atlas, we uncover a topographic
                      gradient of overlapping receptor distributions that
                      separates extrinsic and intrinsic psychological processes.
                      Finally, we find both expected and novel associations
                      between receptor distributions and cortical thinning
                      patterns across 13 disorders. We replicate all findings in
                      an independently collected autoradiography dataset. This
                      work demonstrates how chemoarchitecture shapes brain
                      structure and function, providing a new direction for
                      studying multi-scale brain organization.},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2021.10.28.466336},
      url          = {https://juser.fz-juelich.de/record/903435},
}