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| Hauptseite > Publikationsdatenbank > Mapping neurotransmitter systems to the structural and functional organization of the human neocortex > print |
| Hauptseite > Publikationsdatenbank > Mapping neurotransmitter systems to the structural and functional organization of the human neocortex > print |
| 001 | 903435 | ||
| 005 | 20211212011922.0 | ||
| 024 | 7 | _ | |a 10.1101/2021.10.28.466336 |2 doi |
| 024 | 7 | _ | |a 2128/29423 |2 Handle |
| 024 | 7 | _ | |a altmetric:116005554 |2 altmetric |
| 037 | _ | _ | |a FZJ-2021-05115 |
| 100 | 1 | _ | |a Hansen, Justine Y. |0 0000-0003-3142-7480 |b 0 |
| 245 | _ | _ | |a Mapping neurotransmitter systems to the structural and functional organization of the human neocortex |
| 260 | _ | _ | |c 2021 |
| 336 | 7 | _ | |a Preprint |b preprint |m preprint |0 PUB:(DE-HGF)25 |s 1639059936_7732 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a WORKING_PAPER |2 ORCID |
| 336 | 7 | _ | |a Electronic Article |0 28 |2 EndNote |
| 336 | 7 | _ | |a preprint |2 DRIVER |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Working Paper |2 DataCite |
| 520 | _ | _ | |a Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography scans in >1200 healthy individuals to construct a whole-brain 3-D normative atlas of 18 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization. |
| 536 | _ | _ | |a 5251 - Multilevel Brain Organization and Variability (POF4-525) |0 G:(DE-HGF)POF4-5251 |c POF4-525 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Shafiei, Golia |0 0000-0002-2036-5571 |b 1 |
| 700 | 1 | _ | |a Markello, Ross D. |0 0000-0003-1057-1336 |b 2 |
| 700 | 1 | _ | |a Smart, Kelly |0 0000-0002-4775-6943 |b 3 |
| 700 | 1 | _ | |a Cox, Sylvia M. L. |b 4 |
| 700 | 1 | _ | |a Wu, Yanjun |b 5 |
| 700 | 1 | _ | |a Gallezot, Jean-Dominique |0 0000-0003-0399-8374 |b 6 |
| 700 | 1 | _ | |a Aumont, Étienne |0 0000-0002-8997-7090 |b 7 |
| 700 | 1 | _ | |a Servaes, Stijn |b 8 |
| 700 | 1 | _ | |a Scala, Stephanie G. |b 9 |
| 700 | 1 | _ | |a DuBois, Jonathan M. |0 0000-0002-4629-8354 |b 10 |
| 700 | 1 | _ | |a Wainstein, Gabriel |0 0000-0002-8106-6647 |b 11 |
| 700 | 1 | _ | |a Bezgin, Gleb |0 0000-0002-1069-9201 |b 12 |
| 700 | 1 | _ | |a Funck, Thomas |b 13 |
| 700 | 1 | _ | |a Schmitz, Taylor W. |0 0000-0003-0585-7524 |b 14 |
| 700 | 1 | _ | |a Spreng, R. Nathan |0 0000-0003-1530-8916 |b 15 |
| 700 | 1 | _ | |a Soucy, Jean-Paul |0 0000-0002-8422-2326 |b 16 |
| 700 | 1 | _ | |a Baillet, Sylvain |0 0000-0002-6762-5713 |b 17 |
| 700 | 1 | _ | |a Guimond, Synthia |0 0000-0002-1582-725X |b 18 |
| 700 | 1 | _ | |a Hietala, Jarmo |0 0000-0002-3179-6780 |b 19 |
| 700 | 1 | _ | |a Bédard, Marc-André |b 20 |
| 700 | 1 | _ | |a Leyton, Marco |0 0000-0002-1243-2252 |b 21 |
| 700 | 1 | _ | |a Kobayashi, Eliane |0 0000-0002-1713-1563 |b 22 |
| 700 | 1 | _ | |a Rosa-Neto, Pedro |0 0000-0001-9116-1376 |b 23 |
| 700 | 1 | _ | |a Palomero-Gallagher, Nicola |0 P:(DE-Juel1)131701 |b 24 |
| 700 | 1 | _ | |a Shine, James M. |0 0000-0003-1762-5499 |b 25 |
| 700 | 1 | _ | |a Carson, Richard E. |b 26 |
| 700 | 1 | _ | |a Tuominen, Lauri |0 0000-0002-8726-0467 |b 27 |
| 700 | 1 | _ | |a Dagher, Alain |0 0000-0002-0945-5779 |b 28 |
| 700 | 1 | _ | |a Misic, Bratislav |0 0000-0003-0307-2862 |b 29 |e Corresponding author |
| 773 | _ | _ | |a 10.1101/2021.10.28.466336 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/903435/files/HAnsen_etal_bioRxiv_2021_preprint.pdf |y OpenAccess |
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| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 24 |6 P:(DE-Juel1)131701 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-525 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Decoding Brain Organization and Dysfunction |9 G:(DE-HGF)POF4-5251 |x 0 |
| 914 | 1 | _ | |y 2021 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-1-20090406 |k INM-1 |l Strukturelle und funktionelle Organisation des Gehirns |x 0 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a preprint |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)INM-1-20090406 |
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