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@ARTICLE{Paquola:903462,
      author       = {Paquola, Casey and Garber, Margaret and Frässle, Stefan
                      and Royer, Jessica and Tavakol, Shahin and Rodriguez-Cruces,
                      Raul and Jeffries, Elizabeth and Smallwood, Jonathan and
                      Bernhardt, Boris},
      title        = {{T}he {U}nique {C}ytoarchitecture and {W}iring of the
                      {H}uman {D}efault {M}ode {N}etwork},
      reportid     = {FZJ-2021-05135},
      year         = {2021},
      abstract     = {It is challenging to specify the role of the default mode
                      network (DMN) in human behaviour. Contemporary theories,
                      based on functional magnetic resonance imaging (MRI),
                      suggest that the DMN is insulated from the external world,
                      which allows it to support perceptually-decoupled states and
                      to integrate external and internal information in the
                      construction of abstract meanings. To date, the neuronal
                      architecture of the DMN has received relatively little
                      attention. Understanding the cytoarchitectural composition
                      and connectional layout of the DMN will provide novel
                      insights into its role in brain function. We mapped
                      cytoarchitectural variation within the DMN using a cortical
                      type atlas and a histological model of the entire human
                      brain. Next, we used MRI acquired in healthy young adults to
                      explicate structural wiring and effective connectivity. We
                      discovered profound diversity of DMN cytoarchitecture.
                      Connectivity is organised along the most dominant
                      cytoarchitectural axis. One side of the axis is the
                      prominent receiver, whereas the other side remains more
                      insulated, especially from sensory areas. The structural
                      heterogeneity of the DMN engenders a network-level balance
                      in communication with external and internal sources, which
                      is distinctive, relative to other functional communities.
                      The neuronal architecture of the DMN suggests it is a
                      protuberance from the core cortical processing hierarchy and
                      holds a unique role in information integration.},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5254 - Neuroscientific Data Analytics and AI (POF4-525) /
                      HIBALL - Helmholtz International BigBrain Analytics and
                      Learning Laboratory (HIBALL) (InterLabs-0015)},
      pid          = {G:(DE-HGF)POF4-5254 / G:(DE-HGF)InterLabs-0015},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2021.11.22.469533},
      url          = {https://juser.fz-juelich.de/record/903462},
}