% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Smigielski:903471,
      author       = {Smigielski, Lukasz and Papiol, Sergi and Theodoridou,
                      Anastasia and Heekeren, Karsten and Gerstenberg, Miriam and
                      Wotruba, Diana and Buechler, Roman and Hoffmann, Per and
                      Herms, Stefan and Adorjan, Kristina and Anderson-Schmidt,
                      Heike and Budde, Monika and Comes, Ashley L. and Gade,
                      Katrin and Heilbronner, Maria and Heilbronner, Urs and
                      Kalman, Janos L. and Klöhn-Saghatolislam, Farahnaz and
                      Reich-Erkelenz, Daniela and Schaupp, Sabrina K. and Schulte,
                      Eva C. and Senner, Fanny and Anghelescu, Ion-George and
                      Arolt, Volker and Baune, Bernhard T. and Dannlowski, Udo and
                      Dietrich, Detlef E. and Fallgatter, Andreas J. and Figge,
                      Christian and Jäger, Markus and Juckel, Georg and Konrad,
                      Carsten and Nieratschker, Vanessa and Reimer, Jens and
                      Reininghaus, Eva and Schmauß, Max and Spitzer, Carsten and
                      von Hagen, Martin and Wiltfang, Jens and Zimmermann, Jörg
                      and Gryaznova, Anna and Flatau-Nagel, Laura and Reitt,
                      Markus and Meyers, Milena and Emons, Barbara and
                      Haußleiter, Ida Sybille and Lang, Fabian U. and Becker,
                      Thomas and Wigand, Moritz E. and Witt, Stephanie H. and
                      Degenhardt, Franziska and Forstner, Andreas J. and
                      Rietschel, Marcella and Nöthen, Markus M. and Andlauer,
                      Till F. M. and Rössler, Wulf and Walitza, Susanne and
                      Falkai, Peter and Schulze, Thomas G. and Grünblatt, Edna},
      title        = {{P}olygenic risk scores across the extended psychosis
                      spectrum},
      journal      = {Translational Psychiatry},
      volume       = {11},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2021-05143},
      pages        = {600},
      year         = {2021},
      abstract     = {As early detection of symptoms in the subclinical to
                      clinical psychosis spectrum may improve health outcomes,
                      knowing the probabilistic susceptibility of developing a
                      disorder could guide mitigation measures and clinical
                      intervention. In this context, polygenic risk scores (PRSs)
                      quantifying the additive effects of multiple common genetic
                      variants hold the potential to predict complex diseases and
                      index severity gradients. PRSs for schizophrenia (SZ) and
                      bipolar disorder (BD) were computed using Bayesian
                      regression and continuous shrinkage priors based on the
                      latest SZ and BD genome-wide association studies
                      (Psychiatric Genomics Consortium, third release). Eight
                      well-phenotyped groups (n = 1580; $56\%$ males) were
                      assessed: control (n = 305), lower (n = 117) and
                      higher (n = 113) schizotypy (both groups of healthy
                      individuals), at-risk for psychosis (n = 120), BD type-I
                      (n = 359), BD type-II (n = 96), schizoaffective
                      disorder (n = 86), and SZ groups (n = 384). PRS
                      differences were investigated for binary traits and the
                      quantitative Positive and Negative Syndrome Scale. Both
                      BD-PRS and SZ-PRS significantly differentiated controls from
                      at-risk and clinical groups (Nagelkerke’s pseudo-R2:
                      $1.3–7.7\%),$ except for BD type-II for SZ-PRS. Out of 28
                      pairwise comparisons for SZ-PRS and BD-PRS, 9 and 12,
                      respectively, reached the Bonferroni-corrected significance.
                      BD-PRS differed between control and at-risk groups, but not
                      between at-risk and BD type-I groups. There was no
                      difference between controls and schizotypy. SZ-PRSs, but not
                      BD-PRSs, were positively associated with transdiagnostic
                      symptomology. Overall, PRSs support the continuum model
                      across the psychosis spectrum at the genomic level with
                      possible irregularities for schizotypy. The at-risk state
                      demands heightened clinical attention and research
                      addressing symptom course specifiers. Continued efforts are
                      needed to refine the diagnostic and prognostic accuracy of
                      PRSs in mental healthcare.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34836939},
      UT           = {WOS:000722844000001},
      doi          = {10.1038/s41398-021-01720-0},
      url          = {https://juser.fz-juelich.de/record/903471},
}