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@ARTICLE{Thalamuthu:903474,
      author       = {Thalamuthu, Anbupalam and Mills, Natalie T. and Berger,
                      Klaus and Minnerup, Heike and Grotegerd, Dominik and
                      Dannlowski, Udo and Meinert, Susanne and Opel, Nils and
                      Repple, Jonathan and Gruber, Marius and Nenadić, Igor and
                      Stein, Frederike and Brosch, Katharina and Meller, Tina and
                      Pfarr, Julia-Katharina and Forstner, Andreas J. and
                      Hoffmann, Per and Nöthen, Markus M. and Witt, Stephanie and
                      Rietschel, Marcella and Kircher, Tilo and Adams, Mark and
                      McIntosh, Andrew M. and Porteous, David J. and Deary, Ian J.
                      and Hayward, Caroline and Campbell, Archie and Grabe, Hans
                      Jörgen and Teumer, Alexander and Homuth, Georg and van der
                      Auwera-Palitschka, Sandra and Oliver Schubert, K. and Baune,
                      Bernhard T.},
      title        = {{G}enome-wide interaction study with major depression
                      identifies novel variants associated with cognitive
                      function},
      journal      = {Molecular psychiatry},
      volume       = {27},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2021-05146},
      pages        = {1111–1119},
      year         = {2022},
      abstract     = {Major Depressive Disorder (MDD) often is associated with
                      significant cognitive dysfunction. We conducted a
                      meta-analysis of genome-wide interaction of MDD and
                      cognitive function using data from four large European
                      cohorts in a total of 3510 MDD cases and 6057 controls. In
                      addition, we conducted analyses using polygenic risk scores
                      (PRS) based on data from the Psychiatric Genomics Consortium
                      (PGC) on the traits of MDD, Bipolar disorder (BD),
                      Schizophrenia (SCZ), and mood instability (MIN). Functional
                      exploration contained gene expression analyses and Ingenuity
                      Pathway Analysis (IPA®). We identified a set of
                      significantly interacting single nucleotide polymorphisms
                      (SNPs) between MDD and the genome-wide association study
                      (GWAS) of cognitive domains of executive function,
                      processing speed, and global cognition. Several of these
                      SNPs are located in genes expressed in brain, with important
                      roles such as neuronal development (REST), oligodendrocyte
                      maturation (TNFRSF21), and myelination (ARFGEF1). IPA®
                      identified a set of core genes from our dataset that mapped
                      to a wide range of canonical pathways and biological
                      functions (MPO, FOXO1, PDE3A, TSLP, NLRP9, ADAMTS5, ROBO1,
                      REST). Furthermore, IPA® identified upstream regulator
                      molecules and causal networks impacting on the expression of
                      dataset genes, providing a genetic basis for further
                      clinical exploration (vitamin D receptor, beta-estradiol,
                      tadalafil). PRS of MIN and meta-PRS of MDD, MIN and SCZ were
                      significantly associated with all cognitive domains. Our
                      results suggest several genes involved in physiological
                      processes for the development and maintenance of cognition
                      in MDD, as well as potential novel therapeutic agents that
                      could be explored in patients with MDD associated cognitive
                      dysfunction.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34782712},
      UT           = {WOS:000718698500001},
      doi          = {10.1038/s41380-021-01379-5},
      url          = {https://juser.fz-juelich.de/record/903474},
}