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@ARTICLE{Parker:903486,
      author       = {Parker, AV and Mann, Daniel and Tzokov, SB and Hwang, LC
                      and Bergeron, C.},
      title        = {{T}he structure of the bacterial {DNA} segregation {ATP}ase
                      filament reveals the conformational plasticity of {P}ar{A}
                      upon {DNA} binding},
      journal      = {Nature Communications},
      volume       = {12},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2021-05158},
      pages        = {5166},
      year         = {2021},
      abstract     = {The efficient segregation of replicated genetic material is
                      an essential step for cell division.Bacterial cells use
                      several evolutionarily-distinct genome segregation systems,
                      the mostcommon of which is the type I Par system. It
                      consists of an adapter protein, ParB, that bindsto the DNA
                      cargo via interaction with the parS DNA sequence; and an
                      ATPase, ParA, thatbinds nonspecific DNA and mediates cargo
                      transport. However, the molecular details of howthis system
                      functions are not well understood. Here, we report the
                      cryo-EM structure of theVibrio cholerae ParA2 filament bound
                      to DNA, as well as the crystal structures of this proteinin
                      various nucleotide states. These structures show that ParA
                      forms a left-handed filament onDNA, stabilized by nucleotide
                      binding, and that ParA undergoes profound structural
                      rear-rangements upon DNA binding and filament assembly.
                      Collectively, our data suggest thestructural basis for
                      ParA’s cooperative binding to DNA and the formation of
                      high ParA densityregions on the nucleoid.},
      cin          = {ER-C-3},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34453062},
      UT           = {WOS:000691020900009},
      doi          = {10.1038/s41467-021-25429-2},
      url          = {https://juser.fz-juelich.de/record/903486},
}