000903531 001__ 903531
000903531 005__ 20220103172055.0
000903531 0247_ $$2doi$$a10.3389/fphy.2021.721368
000903531 0247_ $$2Handle$$a2128/29453
000903531 0247_ $$2altmetric$$aaltmetric:117348430
000903531 0247_ $$2WOS$$aWOS:000726554800001
000903531 037__ $$aFZJ-2021-05199
000903531 082__ $$a530
000903531 1001_ $$0P:(DE-Juel1)188512$$aKorculanin, Olivera$$b0$$ufzj
000903531 245__ $$aCompetition Between Red Blood Cell Aggregation and Breakup: Depletion Force due to Filamentous Viruses vs. Shear Flow
000903531 260__ $$aLausanne$$bFrontiers Media$$c2021
000903531 3367_ $$2DRIVER$$aarticle
000903531 3367_ $$2DataCite$$aOutput Types/Journal article
000903531 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1639408947_6298
000903531 3367_ $$2BibTeX$$aARTICLE
000903531 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000903531 3367_ $$00$$2EndNote$$aJournal Article
000903531 520__ $$aHuman blood is a shear-thinning fluid with a complex response that strongly depends on the red blood cell’s (RBC’s) ability to form aggregates, called rouleaux. Despite numerous investigations, microscopic understanding of the break up of RBC aggregates has not been fully elucidated. Here, we present a study of breaking up aggregates consisting of two RBCs (a doublet) during shear flow. We introduce the filamentous fd bacteriophage as a rod-like depletant agent with a very long-range interaction force, which can be tuned by the rod’s concentration. We visualize the structures while shearing by combining a home-build counter-rotating cone-plate shear cell with microscopy imaging. A diagram of dynamic states for shear rates versus depletant concentration shows regions of different flow responses and separation stages for the RBCs doublets. With increasing interaction forces, the full-contact flow states dominate, such as rolling and tumbling. We argue that the RBC doublets can only undergo separation during tumbling motion when the angle between the normal of the doublets with the flow direction is within a critical range. However, at sufficiently high shear rates, the time spent in the critical range becomes too short, such that the cells continue to tumble without separating.
000903531 536__ $$0G:(DE-HGF)POF4-5243$$a5243 - Information Processing in Distributed Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
000903531 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000903531 7001_ $$0P:(DE-Juel1)169845$$aKochetkova, T.$$b1
000903531 7001_ $$0P:(DE-Juel1)130797$$aLettinga, M. P.$$b2$$eCorresponding author$$ufzj
000903531 773__ $$0PERI:(DE-600)2721033-9$$a10.3389/fphy.2021.721368$$gVol. 9, p. 721368$$p721368$$tFrontiers in physics$$v9$$x2296-424X$$y2021
000903531 8564_ $$uhttps://juser.fz-juelich.de/record/903531/files/fphy-09-721368.pdf$$yOpenAccess
000903531 8564_ $$uhttps://juser.fz-juelich.de/record/903531/files/main.pdf$$yOpenAccess
000903531 909CO $$ooai:juser.fz-juelich.de:903531$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000903531 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188512$$aForschungszentrum Jülich$$b0$$kFZJ
000903531 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130797$$aForschungszentrum Jülich$$b2$$kFZJ
000903531 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5243$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
000903531 9141_ $$y2021
000903531 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000903531 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000903531 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT PHYS-LAUSANNE : 2019$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000903531 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-03
000903531 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-03
000903531 920__ $$lyes
000903531 9201_ $$0I:(DE-Juel1)IBI-4-20200312$$kIBI-4$$lBiomakromolekulare Systeme und Prozesse$$x0
000903531 980__ $$ajournal
000903531 980__ $$aVDB
000903531 980__ $$aUNRESTRICTED
000903531 980__ $$aI:(DE-Juel1)IBI-4-20200312
000903531 9801_ $$aFullTexts