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@ARTICLE{Korculanin:903531,
      author       = {Korculanin, Olivera and Kochetkova, T. and Lettinga, M. P.},
      title        = {{C}ompetition {B}etween {R}ed {B}lood {C}ell {A}ggregation
                      and {B}reakup: {D}epletion {F}orce due to {F}ilamentous
                      {V}iruses vs. {S}hear {F}low},
      journal      = {Frontiers in physics},
      volume       = {9},
      issn         = {2296-424X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2021-05199},
      pages        = {721368},
      year         = {2021},
      abstract     = {Human blood is a shear-thinning fluid with a complex
                      response that strongly depends on the red blood cell’s
                      (RBC’s) ability to form aggregates, called rouleaux.
                      Despite numerous investigations, microscopic understanding
                      of the break up of RBC aggregates has not been fully
                      elucidated. Here, we present a study of breaking up
                      aggregates consisting of two RBCs (a doublet) during shear
                      flow. We introduce the filamentous fd bacteriophage as a
                      rod-like depletant agent with a very long-range interaction
                      force, which can be tuned by the rod’s concentration. We
                      visualize the structures while shearing by combining a
                      home-build counter-rotating cone-plate shear cell with
                      microscopy imaging. A diagram of dynamic states for shear
                      rates versus depletant concentration shows regions of
                      different flow responses and separation stages for the RBCs
                      doublets. With increasing interaction forces, the
                      full-contact flow states dominate, such as rolling and
                      tumbling. We argue that the RBC doublets can only undergo
                      separation during tumbling motion when the angle between the
                      normal of the doublets with the flow direction is within a
                      critical range. However, at sufficiently high shear rates,
                      the time spent in the critical range becomes too short, such
                      that the cells continue to tumble without separating.},
      cin          = {IBI-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000726554800001},
      doi          = {10.3389/fphy.2021.721368},
      url          = {https://juser.fz-juelich.de/record/903531},
}