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@ARTICLE{Korculanin:903531,
author = {Korculanin, Olivera and Kochetkova, T. and Lettinga, M. P.},
title = {{C}ompetition {B}etween {R}ed {B}lood {C}ell {A}ggregation
and {B}reakup: {D}epletion {F}orce due to {F}ilamentous
{V}iruses vs. {S}hear {F}low},
journal = {Frontiers in physics},
volume = {9},
issn = {2296-424X},
address = {Lausanne},
publisher = {Frontiers Media},
reportid = {FZJ-2021-05199},
pages = {721368},
year = {2021},
abstract = {Human blood is a shear-thinning fluid with a complex
response that strongly depends on the red blood cell’s
(RBC’s) ability to form aggregates, called rouleaux.
Despite numerous investigations, microscopic understanding
of the break up of RBC aggregates has not been fully
elucidated. Here, we present a study of breaking up
aggregates consisting of two RBCs (a doublet) during shear
flow. We introduce the filamentous fd bacteriophage as a
rod-like depletant agent with a very long-range interaction
force, which can be tuned by the rod’s concentration. We
visualize the structures while shearing by combining a
home-build counter-rotating cone-plate shear cell with
microscopy imaging. A diagram of dynamic states for shear
rates versus depletant concentration shows regions of
different flow responses and separation stages for the RBCs
doublets. With increasing interaction forces, the
full-contact flow states dominate, such as rolling and
tumbling. We argue that the RBC doublets can only undergo
separation during tumbling motion when the angle between the
normal of the doublets with the flow direction is within a
critical range. However, at sufficiently high shear rates,
the time spent in the critical range becomes too short, such
that the cells continue to tumble without separating.},
cin = {IBI-4},
ddc = {530},
cid = {I:(DE-Juel1)IBI-4-20200312},
pnm = {5243 - Information Processing in Distributed Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5243},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000726554800001},
doi = {10.3389/fphy.2021.721368},
url = {https://juser.fz-juelich.de/record/903531},
}