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@ARTICLE{Skoulas:903588,
      author       = {Skoulas, Dimitrios and Mangiapia, Gaetano and Parisi,
                      Daniele and Kasimatis, Maria and Glynos, Emmanouil and
                      Stratikos, Efstratios and Vlassopoulos, Dimitris and
                      Frielinghaus, Henrich and Iatrou, Hermis},
      title        = {{T}unable {H}ydrogels with {I}mproved {V}iscoelastic
                      {P}roperties from {H}ybrid {P}olypeptides},
      journal      = {Macromolecules},
      volume       = {54},
      number       = {23},
      issn         = {0024-9297},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2021-05242},
      pages        = {10786 - 10800},
      year         = {2021},
      abstract     = {Hydrogels that can respond to a number of external stimuli
                      and at the same time show impressive rheological properties
                      are promising materials for a wide range of bioapplications.
                      Here, we present a series of well-defined linear
                      amphiphilic pentablock hybrid polypeptides of the ABCBA
                      type, where A is poly(L-lysine), B is
                      poly(L-histidine)-co-poly(γ-benzyl-L-glutamate), and C is
                      poly(ethylene oxide) (PEO). The polymers were synthesized by
                      the sequential primary amine ring-opening polymerization of
                      N-carboxy anhydrides using bis amine poly(ethylene oxide)
                      (PEO) as a bifunctional macroinitiator, and the length of
                      all of the blocks was varied. The resulting materials formed
                      novel extrudable in situ forming quickly self-healing
                      hydrogels, responsive to the alteration of pH and increase
                      of temperature. The connection between the alteration of the
                      secondary structure of the polypeptides with the
                      viscoelastic behavior was revealed by means of rheology and
                      circular dichroism. Small-angle neutron scattering and
                      scanning electron microscopy were employed to shed light on
                      the structure of the polymers and how it affects their
                      rheological properties. The obtained polymers were subjected
                      to enzymatic degradation tests with trypsin and leucine
                      aminopeptidase. The results suggest that these biomaterials
                      have the potential to be used in a number of bioapplications
                      like drug delivery, 3D printing, and tissue engineering.},
      cin          = {JCNS-FRM-II / JCNS-1 / JCNS-4 / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012 /
                      I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000752886100016},
      doi          = {10.1021/acs.macromol.1c01596},
      url          = {https://juser.fz-juelich.de/record/903588},
}