TY  - JOUR
AU  - Grefkes, C.
AU  - Wang, L.E.
AU  - Eickhoff, S. B.
AU  - Fink, G. R.
TI  - Noradrenergic Modulation of Cortical Networks Engaged in Visuomotor Processing
JO  - Cerebral cortex
VL  - 20
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-9036
SP  - 783 - 797
PY  - 2010
N1  - Marie Curie Early Stage Training Programme "NovoBrain'' funded by the European Union to L. E. W.; Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology to S. B. E.
AB  - Both animal and human data suggest that stimulation of the noradrenergic system may influence neuronal excitability in regions engaged in sensory processing and visuospatial attention. We tested the hypothesis that the neural mechanisms subserving motor performance in tasks relying on the visuomotor control of goal-directed hand movements might be modulated by noradrenergic influences. Healthy subjects were stimulated using the selective noradrenaline reuptake inhibitor reboxetine (RBX) in a placebo-controlled crossover design. Functional magnetic resonance imaging and dynamic causal modeling (DCM) were used to assess drug-related changes in blood oxygen level-dependent activity and interregional connectivity while subjects performed a joystick task requiring goal-directed movements. Improved task performance under RBX was associated with increased activity in right visual, intraparietal and superior frontal cortex (premotor/frontal eye field). DCM revealed that the neuronal coupling among these regions was significantly enhanced when subjects were stimulated with RBX. Concurrently, right intraparietal cortex and right superior frontal cortex exerted a stronger driving influence on visuomotor areas of the left hemisphere, including SMA and M1. These effects were independent from task difficulty. The data suggest that stimulating noradrenergic mechanisms may rearrange the functional network architecture within and across the hemispheres, for example, by synaptic gating, thereby optimizing motor behavior.
KW  - Adrenergic Uptake Inhibitors: pharmacology
KW  - Adult
KW  - Analysis of Variance
KW  - Bayes Theorem
KW  - Brain Mapping
KW  - Cerebral Cortex: blood supply
KW  - Cerebral Cortex: drug effects
KW  - Cerebral Cortex: metabolism
KW  - Cerebral Cortex: physiology
KW  - Double-Blind Method
KW  - Female
KW  - Functional Laterality: drug effects
KW  - Humans
KW  - Image Processing, Computer-Assisted: methods
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Models, Neurological
KW  - Morpholines: pharmacology
KW  - Neural Pathways: blood supply
KW  - Neural Pathways: drug effects
KW  - Neural Pathways: physiology
KW  - Norepinephrine: metabolism
KW  - Oxygen: blood
KW  - Photic Stimulation: methods
KW  - Psychomotor Performance: drug effects
KW  - Psychomotor Performance: physiology
KW  - Time Factors
KW  - Young Adult
KW  - Adrenergic Uptake Inhibitors (NLM Chemicals)
KW  - Morpholines (NLM Chemicals)
KW  - Norepinephrine (NLM Chemicals)
KW  - Oxygen (NLM Chemicals)
KW  - reboxetine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19687293
UR  - <Go to ISI:>//WOS:000275566500003
DO  - DOI:10.1093/cercor/bhp144
UR  - https://juser.fz-juelich.de/record/9036
ER  -