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000903605 1001_ $$0P:(DE-HGF)0$$aBogorodskiy, Andrey$$b0
000903605 245__ $$aRole of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases
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000903605 520__ $$aMitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.
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000903605 7001_ $$00000-0002-1053-2778$$aOkhrimenko, Ivan$$b1
000903605 7001_ $$00000-0003-3667-1159$$aBurkatovskii, Dmitrii$$b2
000903605 7001_ $$0P:(DE-HGF)0$$aJakobs, Philipp$$b3
000903605 7001_ $$0P:(DE-HGF)0$$aMaslov, Ivan$$b4
000903605 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b5$$ufzj
000903605 7001_ $$0P:(DE-HGF)0$$aDencher, Norbert A.$$b6
000903605 7001_ $$0P:(DE-Juel1)131924$$aGensch, Thomas$$b7
000903605 7001_ $$0P:(DE-HGF)0$$aVoos, Wolfgang$$b8
000903605 7001_ $$0P:(DE-HGF)0$$aAltschmied, Joachim$$b9
000903605 7001_ $$00000-0001-8507-4540$$aHaendeler, Judith$$b10
000903605 7001_ $$0P:(DE-Juel1)144613$$aBorshchevskiy, Valentin$$b11$$eCorresponding author
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