TY  - JOUR
AU  - Bogorodskiy, Andrey
AU  - Okhrimenko, Ivan
AU  - Burkatovskii, Dmitrii
AU  - Jakobs, Philipp
AU  - Maslov, Ivan
AU  - Gordeliy, Valentin
AU  - Dencher, Norbert A.
AU  - Gensch, Thomas
AU  - Voos, Wolfgang
AU  - Altschmied, Joachim
AU  - Haendeler, Judith
AU  - Borshchevskiy, Valentin
TI  - Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases
JO  - Cells
VL  - 10
IS  - 12
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - FZJ-2021-05259
SP  - 3528 -
PY  - 2021
AB  - Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.
LB  - PUB:(DE-HGF)16
C6  - pmid:34944035
UR  - <Go to ISI:>//WOS:000741498500001
DO  - DOI:10.3390/cells10123528
UR  - https://juser.fz-juelich.de/record/903605
ER  -