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@ARTICLE{Bogorodskiy:903605,
      author       = {Bogorodskiy, Andrey and Okhrimenko, Ivan and Burkatovskii,
                      Dmitrii and Jakobs, Philipp and Maslov, Ivan and Gordeliy,
                      Valentin and Dencher, Norbert A. and Gensch, Thomas and
                      Voos, Wolfgang and Altschmied, Joachim and Haendeler, Judith
                      and Borshchevskiy, Valentin},
      title        = {{R}ole of {M}itochondrial {P}rotein {I}mport in
                      {A}ge-{R}elated {N}eurodegenerative and {C}ardiovascular
                      {D}iseases},
      journal      = {Cells},
      volume       = {10},
      number       = {12},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-05259},
      pages        = {3528 -},
      year         = {2021},
      abstract     = {Mitochondria play a critical role in providing energy,
                      maintaining cellular metabolism, and regulating cell
                      survival and death. To carry out these crucial functions,
                      mitochondria employ more than 1500 proteins, distributed
                      between two membranes and two aqueous compartments. An
                      extensive network of dedicated proteins is engaged in
                      importing and sorting these nuclear-encoded proteins into
                      their designated mitochondrial compartments. Defects in this
                      fundamental system are related to a variety of pathologies,
                      particularly engaging the most energy-demanding tissues. In
                      this review, we summarize the state-of-the-art knowledge
                      about the mitochondrial protein import machinery and
                      describe the known interrelation of its failure with
                      age-related neurodegenerative and cardiovascular diseases.},
      cin          = {IBI-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34944035},
      UT           = {WOS:000741498500001},
      doi          = {10.3390/cells10123528},
      url          = {https://juser.fz-juelich.de/record/903605},
}