TY  - JOUR
AU  - Gehlen, Jana
AU  - Aretzweiler, Christoph
AU  - Mataruga, Anja
AU  - Fahlke, Christoph
AU  - Müller, Frank
TI  - Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina
JO  - eNeuro
VL  - 8
IS  - 6
SN  - 2373-2822
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2021-05260
SP  - ENEURO.0406-21.2021 -
PY  - 2021
AB  - Excitatory amino acid transporters (EAATs) remove glutamate from the synaptic cleft. In the retina, EAAT1 and EAAT2 are considered the major glutamate transporters. However, it has not yet been possible to determine how EAAT5 shapes the retinal light responses because of the lack of a selective EAAT5 blocker or EAAT5 knock-out (KO) animal model. In this study, EAAT5 was found to be expressed in a punctate manner close to release sites of glutamatergic synapses in the mouse retina. Light responses from retinae of wild-type (WT) and of a newly generated model with a targeted deletion of EAAT5 (EAAT5−/−) were recorded in vitro using multielectrode arrays (MEAs). Flicker resolution was considerably lower in EAAT5−/− retinae than in WT retinae. The close proximity to the glutamate release site makes EAAT5 an ideal tool to improve temporal information processing in the retina by controlling information transfer at glutamatergic synapses.
LB  - PUB:(DE-HGF)16
C6  - pmid:34772693
DO  - DOI:10.1523/ENEURO.0406-21.2021
UR  - https://juser.fz-juelich.de/record/903606
ER  -