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@INPROCEEDINGS{Kasper:903613,
      author       = {Kasper, Jan and Eickhoff, Simon B. and Peter, Jessica and
                      Dogan, Imis and Wolf, Robert Christian and Reetz, Kathrin
                      and Dukart, Juergen and Orth, Michael},
      title        = {{F}unctional {MRI} {D}erived {R}esting-{S}tate
                      {A}lterations in {H}untington’s {D}isease are {A}ssociated
                      {W}ith the {D}istribution of {S}erotonergic and
                      {D}opaminergic {N}eurotransmitter {S}ystems},
      reportid     = {FZJ-2021-05267},
      year         = {2021},
      abstract     = {Huntington’s disease (HD) is characterized by progressive
                      striatal atrophy and widespreaddegeneration during the
                      course of disease. Functionally, altered resting-state
                      activity andconnectivity in networks involving cortical,
                      subcortical and cerebellar regions can beobserved. The
                      relationship of brain alterations in HD with specific
                      neurotransmitter systemsremains largely unknown. We
                      evaluated whether resting-state alterations in HD are
                      associated with the known in vivodistribution of various
                      neurotransmitter systems including serotonin, GABA, dopamine
                      andnorepinephrine. Maps of resting-state activity derived
                      from functional magnetic resonanceimaging were computed for
                      32 HD patients and 30 healthy controls. We tested
                      whetheralterations in HD were associated with the
                      distribution of specific neurotransmitter systemsand their
                      coding mRNA gene expressions. Finally, we examined the
                      association of theserelationships with HD clinical
                      phenotypes and if these associations can be replicated in
                      anindependent cohort (HD: N=29; controls: N=39).HD
                      functional alterations were significantly related to the
                      distribution of dopamine andserotonin receptors (D1, D2,
                      5-HT1b) and transporters, as well as with mRNA expressions
                      ofgenes encoding the corresponding dopamine proteins. The
                      co-localization with D1 wascorrelated in HD with motor
                      (r=-0.5,p=0.004) and functional (r=0.5,p=0.003)
                      impairment.These findings were largely replicated in a
                      second cohort.We show that resting-state functional
                      alterations in HD follow the spatial distribution
                      ofdopaminergic and serotonergic systems. The strength of
                      these associations was linked to theobserved symptom
                      severity. These findings provide novel insight
                      intoneuropathophysiological mechanisms underlying functional
                      alterations in HD and thisapproach may aid characterizing
                      less researched neurodegenerative diseases.},
      month         = {Apr},
      date          = {2021-04-29},
      organization  = {Society of Biological Psychiatry,
                       Digital (USA), 29 Apr 2021 - 1 May
                       2021},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)1},
      doi          = {10.1016/j.biopsych.2021.02.440},
      url          = {https://juser.fz-juelich.de/record/903613},
}