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@ARTICLE{Endepols:903942,
      author       = {Endepols, Heike and Zlatopolskiy, Boris and Zischler,
                      Johannes and Alavinejad, Nazanin and Apetz, Nadine and Vus,
                      Stefanie and Drzezga, Alexander and Neumaier, Bernd},
      title        = {{I}maging of cerebral tryptophan metabolism using
                      7-[18{F}]{FT}rp-{PET} in a unilateral {P}arkinsonian rat
                      model},
      journal      = {NeuroImage},
      volume       = {247},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2021-05550},
      pages        = {118842 -},
      year         = {2022},
      abstract     = {Degradation products of the essential amino acid tryptophan
                      (Trp) are important signaling molecules in the mammalian
                      brain. Trp is metabolized either through the kynurenine
                      pathway or enters serotonin and melatonin syntheses. The aim
                      of the present work was to examine the potential of the
                      novel PET tracer 7-[18F]fluorotryptophan ([18F]FTrp) to
                      visualize all three pathways in a unilateral 6-OHDA rat
                      model. [18F]FDOPA-PET scans were performed in nine
                      6-OHDA-injected and six sham-operated rats to assess
                      unilateral dopamine depletion severity four weeks after
                      lesion placement. Afterwards, 7-[18F]FTrp-PET scans were
                      conducted at different timepoints up to seven months after
                      6-OHDA injection. In addition, three 6-OHDA-injected rats
                      and one healthy control were examined for neuroinflammation
                      using [18F]DAA1106-PET. 7-[18F]FTrp-PET showed significantly
                      increased tracer uptake at the 6-OHDA injection site which
                      was negatively correlated to time after lesion placement.
                      Accumulation of [18F]DAA1106 at the injection site was
                      increased as well, suggesting that 7-[18F]FTrp uptake in
                      this region may reflect kynurenine pathway activity
                      associated with inflammation. Bilaterally in the dorsal
                      hippocampus, 7-[18F]FTrp uptake was significantly decreased
                      and was inversely correlated to dopamine depletion severity,
                      indicating that it reflects reduced serotonin synthesis.
                      Finally, 7-[18F]FTrp uptake in the pineal gland was
                      significantly increased in relation with dopamine depletion
                      severity, providing evidence that melatonin synthesis is
                      increased in the 6-OHDA rat model. We conclude that
                      7-[18F]FTrp is able to detect alterations in both
                      serotonin/melatonin and kynurenine metabolic pathways, and
                      can be applied to visualize pathologic changes related to
                      neurodegenerative processes.},
      cin          = {INM-5 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34942366},
      UT           = {WOS:000736962400011},
      doi          = {10.1016/j.neuroimage.2021.118842},
      url          = {https://juser.fz-juelich.de/record/903942},
}