TY  - JOUR
AU  - Waldmann, Moritz
AU  - Grosch, Alice
AU  - Witzler, Christian
AU  - Lehner, Matthias
AU  - Benda, Odo
AU  - Koch, Walter
AU  - Vogt, Klaus
AU  - Kohn, Christopher
AU  - Schröder, Wolfgang
AU  - Göbbert, Jens Henrik
AU  - Lintermann, Andreas
TI  - An effective simulation- and measurement-based workflow for enhanced diagnostics in rhinology
JO  - Medical & biological engineering & computing
VL  - 60
IS  - 2
SN  - 0140-0118
CY  - Heidelberg
PB  - Springer
M1  - FZJ-2021-05692
SP  - 365-391
PY  - 2022
AB  - Physics-based analyses have the potential to consolidate and substantiate medical diagnoses in rhinology. Such methods are frequently subject to intense investigations in research. However, they are not used in clinical applications, yet. One issue preventing their direct integration is that these methods are commonly developed as isolated solutions which do not consider the whole chain of data processing from initial medical to higher valued data. This manuscript presents a workflow that incorporates the whole data processing pipeline based on a environment. Therefore, medical image data are fully automatically pre-processed by machine learning algorithms. The resulting geometries employed for the simulations on high-performance computing systems reach an accuracy of up to 99.5% compared to manually segmented geometries. Additionally, the user is enabled to upload and visualize 4-phase rhinomanometry data. Subsequent analysis and visualization of the simulation outcome extend the results of standardized diagnostic methods by a physically sound interpretation. Along with a detailed presentation of the methodologies, the capabilities of the workflow are demonstrated by evaluating an exemplary medical case. The pipeline output is compared to 4-phase rhinomanometry data. The comparison underlines the functionality of the pipeline. However, it also illustrates the influence of mucosa swelling on the simulation.
LB  - PUB:(DE-HGF)16
C6  - 34950998
UR  - <Go to ISI:>//WOS:000733700900001
DO  - DOI:10.1007/s11517-021-02446-3
UR  - https://juser.fz-juelich.de/record/904122
ER  -