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@ARTICLE{LeiteDantas:904293,
      author       = {Leite Dantas, Rafael and Freff, Jana and Ambrée, Oliver
                      and Beins, Eva C. and Forstner, Andreas J. and Dannlowski,
                      Udo and Baune, Bernhard T. and Scheu, Stefanie and Alferink,
                      Judith},
      title        = {{D}endritic {C}ells: {N}eglected {M}odulators of
                      {P}eripheral {I}mmune {R}esponses and {N}euroinflammation in
                      {M}ood {D}isorders?},
      journal      = {Cells},
      volume       = {10},
      number       = {4},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-05863},
      pages        = {941 -},
      year         = {2021},
      abstract     = {Affective disorders (AD) including major depressive
                      disorder (MDD) and bipolar disorder (BD) are common mood
                      disorders associated with increased disability and poor
                      health outcomes. Altered immune responses characterized by
                      increased serum levels of pro-inflammatory cytokines and
                      neuroinflammation are common findings in patients with AD
                      and in corresponding animal models. Dendritic cells (DCs)
                      represent a heterogeneous population of myeloid cells that
                      orchestrate innate and adaptive immune responses and
                      self-tolerance. Upon sensing exogenous and endogenous danger
                      signals, mature DCs secrete proinflammatory factors, acquire
                      migratory and antigen presenting capacities and thus
                      contribute to neuroinflammation in trauma, autoimmunity, and
                      neurodegenerative diseases. However, little is known about
                      the involvement of DCs in the pathogenesis of AD. In this
                      review, we summarize the current knowledge on DCs in
                      peripheral immune responses and neuroinflammation in MDD and
                      BD. In addition, we consider the impact of DCs on
                      neuroinflammation and behavior in animal models of AD.
                      Finally, we will discuss therapeutic perspectives targeting
                      DCs and their effector molecules in mood disorders.},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33921690},
      UT           = {WOS:000642854600001},
      doi          = {10.3390/cells10040941},
      url          = {https://juser.fz-juelich.de/record/904293},
}