% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Chiotis:904299,
      author       = {Chiotis, Konstantinos and Dodich, Alessandra and Boccardi,
                      Marina and Festari, Cristina and Drzezga, Alexander and
                      Hansson, Oskar and Ossenkoppele, Rik and Frisoni, Giovanni
                      and Garibotto, Valentina and Nordberg, Agneta},
      title        = {{C}linical validity of increased cortical binding of tau
                      ligands of the {THK} family and {PBB}3 on {PET} as
                      biomarkers for {A}lzheimer’s disease in the context of a
                      structured 5-phase development framework},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {48},
      number       = {7},
      issn         = {0340-6997},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2021-05869},
      pages        = {2086 - 2096},
      year         = {2021},
      abstract     = {Purpose: The research community has focused on defining
                      reliable biomarkers for the early detection of the
                      pathological hallmarks of Alzheimer's disease (AD). In 2017,
                      the Geneva AD Biomarker Roadmap initiative adapted the
                      framework for the systematic validation of oncological
                      biomarkers to AD, with the aim to accelerate their
                      development and implementation in clinical practice. The aim
                      of this work was to assess the validation status of tau PET
                      ligands of the THK family and PBB3 as imaging biomarkers for
                      AD, based on the Biomarker Roadmap methodology.Methods: A
                      panel of experts in AD biomarkers convened in November 2019
                      at a 2-day workshop in Geneva. The level of clinical
                      validity of tau PET ligands of the THK family and PBB3 was
                      assessed based on the 5-phase development framework before
                      the meeting and discussed during the workshop.Results: PET
                      radioligands of the THK family discriminate well between
                      healthy controls and patients with AD dementia (phase 2;
                      partly achieved) and recent evidence suggests an accurate
                      diagnostic accuracy at the mild cognitive impairment (MCI)
                      stage of the disease (phase 3; partly achieved). The phases
                      2 and 3 were considered not achieved for PBB3 since no
                      evidence exists about the ligand's diagnostic accuracy.
                      Preliminary evidence exists about the secondary aims of each
                      phase for all ligands.Conclusion: Much work remains for
                      completing the aims of phases 2 and 3 and replicating the
                      available evidence. However, it is unlikely that the
                      validation process for these tracers will be completed,
                      given the presence of off-target binding and the development
                      of second-generation tracers with improved binding and
                      pharmacokinetic properties.Keywords: Alzheimer’s disease;
                      Biomarker-based diagnosis; PBB3; Strategic roadmap; THK; Tau
                      PET.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33723628},
      UT           = {WOS:000629198800001},
      doi          = {10.1007/s00259-021-05277-4},
      url          = {https://juser.fz-juelich.de/record/904299},
}