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@ARTICLE{Attah:904304,
author = {Attah, Alfred Francis and Fagbemi, Adeshola Adebayo and
Olubiyi, Olujide and Dada-Adegbola, Hannah and Oluwadotun,
Akinseinde and Elujoba, Anthony and Babalola, Chinedum
Peace},
title = {{C}orrigendum: {T}herapeutic {P}otentials of {A}ntiviral
{P}lants {U}sed in {T}raditional {A}frican {M}edicine {W}ith
{COVID}-19 in {F}ocus: {A} {N}igerian {P}erspective},
journal = {Frontiers in pharmacology},
volume = {12},
issn = {1663-9812},
address = {Lausanne},
publisher = {Frontiers Media},
reportid = {FZJ-2021-05874},
pages = {721060},
year = {2021},
abstract = {The coronavirus disease 2019 (COVID-19) pandemic is caused
by an infectious novel strain of coronavirus known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which
was earlier referred to as 2019-nCoV. The respiratory
disease is the most consequential global public health
crisis of the 21st century whose level of negative impact
increasingly experienced globally has not been recorded
since World War II. Up till now, there has been no specific
globally authorized antiviral drug, vaccines, supplement or
herbal remedy available for the treatment of this lethal
disease except preventive measures, supportive care and
non-specific treatment options adopted in different
countries via divergent approaches to halt the pandemic.
However, many of these interventions have been documented to
show some level of success particularly the Traditional
Chinese Medicine while there is paucity of well reported
studies on the impact of the widely embraced Traditional
African Medicines (TAM) adopted so far for the prevention,
management and treatment of COVID-19. We carried out a
detailed review of publicly available data, information and
claims on the potentials of indigenous plants used in
Sub-Saharan Africa as antiviral remedies with potentials for
the prevention and management of COVID-19. In this review,
we have provided a holistic report on evidence-based
antiviral and promising anti-SARS-CoV-2 properties of
African medicinal plants based on in silico evidence, in
vitro assays and in vivo experiments alongside the available
data on their mechanistic pharmacology. In addition, we have
unveiled knowledge gaps, provided an update on the effort of
African Scientific community toward demystifying the
dreadful SARS-CoV-2 micro-enemy of man and have documented
popular anti-COVID-19 herbal claims emanating from the
continent for the management of COVID-19 while the risk
potentials of herb-drug interaction of antiviral
phytomedicines when used in combination with orthodox drugs
have also been highlighted. This review exercise may lend
enough credence to the potential value of African medicinal
plants as possible leads in anti-COVID-19 drug discovery
through research and development.},
cin = {IBI-7},
ddc = {610},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5244 - Information Processing in Neuronal Networks
(POF4-524)},
pid = {G:(DE-HGF)POF4-5244},
typ = {PUB:(DE-HGF)16},
pubmed = {34354598},
UT = {WOS:000697366700001},
doi = {10.3389/fphar.2021.721060},
url = {https://juser.fz-juelich.de/record/904304},
}