% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bernardes:904307,
      author       = {Bernardes, Juliana S. and Eberle, Raphael J. and Vieira,
                      Fabio R. J. and Coronado, Mônika A.},
      title        = {{A} comparative pan-genomic analysis of 53 {C}.
                      pseudotuberculosis strains based on functional domains},
      journal      = {Journal of biomolecular structure $\&$ dynamics},
      volume       = {39},
      number       = {18},
      issn         = {0739-1102},
      address      = {Abingdon [u.a.]},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {FZJ-2021-05877},
      pages        = {6974 - 6986},
      year         = {2021},
      abstract     = {Corynebacterium pseudotuberculosis is a pathogenic
                      bacterium with great veterinary and economic importance. It
                      is classified into two biovars: ovis, nitrate-negative, that
                      causes lymphadenitis in small ruminants and equi,
                      nitrate-positive, causing ulcerative lymphangitis in
                      equines. With the explosive growth of available genomes of
                      several strains, pan-genome analysis has opened new
                      opportunities for understanding the dynamics and evolution
                      of C. pseudotuberculosis. However, few pan-genomic studies
                      have compared biovars equi and ovis. Such studies have
                      considered a reduced number of strains and compared entire
                      genomes. Here we conducted an original pan-genome analysis
                      based on protein sequences and their functional domains. We
                      considered 53 C. pseudotuberculosis strains from both
                      biovars isolated from different hosts and countries. We have
                      analysed conserved domains, common domains more frequently
                      found in each biovar and biovar-specific (unique) domains.
                      Our results demonstrated that biovar equi is more variable;
                      there is a significant difference in the number of proteins
                      per strains, probably indicating the occurrence of more gene
                      loss/gain events. Moreover, strains of biovar equi presented
                      a higher number of biovar-specific domains, 77 against only
                      eight in biovar ovis, most of them are associated with
                      virulence mechanisms. With this domain analysis, we have
                      identified functional differences among strains of biovars
                      ovis and equi that could be related to niche-adaptation and
                      probably help to better understanding mechanisms of
                      virulence and pathogenesis. The distribution patterns of
                      functional domains identified in this work might have
                      impacts on bacterial physiology and lifestyle, encouraging
                      the development of new diagnoses, vaccines, and treatments
                      for C. pseudotuberculosis diseases.Communicated by Ramaswamy
                      H. Sarma.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32779519},
      UT           = {WOS:000557983700001},
      doi          = {10.1080/07391102.2020.1805017},
      url          = {https://juser.fz-juelich.de/record/904307},
}