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000904324 1001_ $$0P:(DE-HGF)0$$aSchmitz, Katharina$$b0
000904324 245__ $$aAn essential role of the autophagy activating kinase ULK1 in snRNP biogenesis
000904324 260__ $$aOxford$$bOxford Univ. Press$$c2021
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000904324 520__ $$aThe biogenesis of small uridine-rich nuclear ribonucleoproteins (UsnRNPs) depends on the methylation of Sm proteins catalyzed by the methylosome and the subsequent action of the SMN complex, which assembles the heptameric Sm protein ring onto small nuclear RNAs (snRNAs). In this sophisticated process, the methylosome subunit pICln (chloride conductance regulatory protein) is attributed to an exceptional key position as an ‘assembly chaperone’ by building up a stable precursor Sm protein ring structure. Here, we show that—apart from its autophagic role—the Ser/Thr kinase ULK1 (Uncoordinated [unc-51] Like Kinase 1) functions as a novel key regulator in UsnRNP biogenesis by phosphorylation of the C-terminus of pICln. As a consequence, phosphorylated pICln is no longer capable to hold up the precursor Sm ring structure. Consequently, inhibition of ULK1 results in a reduction of efficient UsnRNP core assembly. Thus ULK1, depending on its complex formation, exerts different functions in autophagy or snRNP biosynthesis.
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000904324 7001_ $$0P:(DE-HGF)0$$aCox, Jan$$b1
000904324 7001_ $$0P:(DE-HGF)0$$aEsser, Lea Marie$$b2
000904324 7001_ $$0P:(DE-HGF)0$$aVoss, Martin$$b3
000904324 7001_ $$0P:(DE-HGF)0$$aSander, Katja$$b4
000904324 7001_ $$0P:(DE-HGF)0$$aLöffler, Antje$$b5
000904324 7001_ $$0P:(DE-HGF)0$$aHillebrand, Frank$$b6
000904324 7001_ $$00000-0003-4763-1240$$aErkelenz, Steffen$$b7
000904324 7001_ $$00000-0002-1636-4365$$aSchaal, Heiner$$b8
000904324 7001_ $$0P:(DE-HGF)0$$aKähne, Thilo$$b9
000904324 7001_ $$0P:(DE-Juel1)161261$$aKlinker, Stefan$$b10
000904324 7001_ $$0P:(DE-HGF)0$$aZhang, Tao$$b11
000904324 7001_ $$0P:(DE-Juel1)162443$$aNagel-Steger, Luitgard$$b12
000904324 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b13
000904324 7001_ $$0P:(DE-HGF)0$$aSeggewiß, Sabine$$b14
000904324 7001_ $$0P:(DE-HGF)0$$aSchlütermann, David$$b15
000904324 7001_ $$0P:(DE-HGF)0$$aStork, Björn$$b16
000904324 7001_ $$0P:(DE-HGF)0$$aGrimmler, Matthias$$b17
000904324 7001_ $$0P:(DE-HGF)0$$aWesselborg, Sebastian$$b18
000904324 7001_ $$00000-0002-0048-2279$$aPeter, Christoph$$b19$$eCorresponding author
000904324 773__ $$0PERI:(DE-600)1472175-2$$a10.1093/nar/gkab452$$gVol. 49, no. 11, p. 6437 - 6455$$n11$$p6437 - 6455$$tNucleic acids research$$v49$$x0301-5610$$y2021
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