% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Risi:904326,
      author       = {Risi, Cristina and Schäfer, Luisa U. and Belknap, Betty
                      and Pepper, Ian and White, Howard D. and Schröder, Gunnar
                      F. and Galkin, Vitold E.},
      title        = {{H}igh-{R}esolution {C}ryo-{EM} {S}tructure of the
                      {C}ardiac {A}ctomyosin {C}omplex},
      journal      = {Structure},
      volume       = {29},
      number       = {1},
      issn         = {0969-2126},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {FZJ-2021-05896},
      pages        = {50 - 60.e4},
      year         = {2021},
      abstract     = {Heart contraction depends on a complicated array of
                      interactions between sarcomeric proteins required to convert
                      chemical energy into mechanical force. Cyclic interactions
                      between actin and myosin molecules, controlled by troponin
                      and tropomyosin, generate the sliding force between the
                      actin-based thin and myosin-based thick filaments.
                      Alterations in this sophisticated system due to missense
                      mutations can lead to cardiovascular diseases. Numerous
                      structural studies proposed pathological mechanisms of
                      missense mutations at the myosin-myosin, actin-tropomyosin,
                      and tropomyosin-troponin interfaces. However, despite the
                      central role of actomyosin interactions a detailed
                      structural description of the cardiac actomyosin interface
                      remained unknown. Here, we report a cryo-EM structure of a
                      cardiac actomyosin complex at 3.8 Å resolution. The
                      structure reveals the molecular basis of cardiac diseases
                      caused by missense mutations in myosin and actin proteins.},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33065066},
      UT           = {WOS:000606462800007},
      doi          = {10.1016/j.str.2020.09.013},
      url          = {https://juser.fz-juelich.de/record/904326},
}