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@ARTICLE{Risi:904326,
author = {Risi, Cristina and Schäfer, Luisa U. and Belknap, Betty
and Pepper, Ian and White, Howard D. and Schröder, Gunnar
F. and Galkin, Vitold E.},
title = {{H}igh-{R}esolution {C}ryo-{EM} {S}tructure of the
{C}ardiac {A}ctomyosin {C}omplex},
journal = {Structure},
volume = {29},
number = {1},
issn = {0969-2126},
address = {Cambridge, Mass.},
publisher = {Cell Press},
reportid = {FZJ-2021-05896},
pages = {50 - 60.e4},
year = {2021},
abstract = {Heart contraction depends on a complicated array of
interactions between sarcomeric proteins required to convert
chemical energy into mechanical force. Cyclic interactions
between actin and myosin molecules, controlled by troponin
and tropomyosin, generate the sliding force between the
actin-based thin and myosin-based thick filaments.
Alterations in this sophisticated system due to missense
mutations can lead to cardiovascular diseases. Numerous
structural studies proposed pathological mechanisms of
missense mutations at the myosin-myosin, actin-tropomyosin,
and tropomyosin-troponin interfaces. However, despite the
central role of actomyosin interactions a detailed
structural description of the cardiac actomyosin interface
remained unknown. Here, we report a cryo-EM structure of a
cardiac actomyosin complex at 3.8 Å resolution. The
structure reveals the molecular basis of cardiac diseases
caused by missense mutations in myosin and actin proteins.},
cin = {IBI-7},
ddc = {540},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5244 - Information Processing in Neuronal Networks
(POF4-524)},
pid = {G:(DE-HGF)POF4-5244},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33065066},
UT = {WOS:000606462800007},
doi = {10.1016/j.str.2020.09.013},
url = {https://juser.fz-juelich.de/record/904326},
}