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@ARTICLE{Pothula:904328,
      author       = {Pothula, Karunakar R. and Geraets, James A. and Ferber,
                      Inda I. and Schröder, Gunnar F.},
      title        = {{C}lustering polymorphs of tau and {IAPP} fibrils with the
                      {CHEP} algorithm},
      journal      = {Progress in biophysics $\&$ molecular biology},
      volume       = {160},
      issn         = {0079-6107},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-05898},
      pages        = {16 - 25},
      year         = {2021},
      abstract     = {Recent steps towards automation have improved the quality
                      and efficiency of the entire cryo-electron microscopy
                      workflow, from sample preparation to image processing. Most
                      of the image processing steps are now quite automated, but
                      there are still a few steps which need the specific
                      intervention of researchers. One such step is the
                      identification and separation of helical protein polymorphs
                      at early stages of image processing. Here, we tested and
                      evaluated our recent clustering approach on three datasets
                      containing amyloid fibrils, demonstrating that the proposed
                      unsupervised clustering method automatically and effectively
                      identifies the polymorphs from cryo-EM images. As an
                      automated polymorph separation method, it has the potential
                      to complement automated helical picking, which typically
                      cannot easily distinguish between polymorphs with subtle
                      differences in morphology, and is therefore a useful tool
                      for the image processing and structure determination of
                      helical proteins.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33556421},
      UT           = {WOS:000632013800004},
      doi          = {10.1016/j.pbiomolbio.2020.11.007},
      url          = {https://juser.fz-juelich.de/record/904328},
}